Inhibition of thromboxane synthetase with 3-(heteroalkyl)-indoly

Details Inhibition of thromboxane synthetase with 3-(heteroalkyl)-indoly Inhibition of thromboxane synthetase with 3-(heteroalkyl)-indoly

1982-07-02

1984-05-29

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424273R, 546273, 548336, A61K 31415, C07D40306

Patent

active

044514727

ABSTRACT:
A series of novel 3-(1-imidazolylmethyl)indolylacrylic acid and 3-(3-pyridylmethyl)indolylacrylic acid derivatives has been prepared, including their pharmaceutically acceptable acid addition and base salts. These particular compounds are useful in therapy for the treatment of thrombosis, ischaemic heart disease, stroke, transient ischaemic attack, migraine, and the vascular complications of diabetes. Preferred member compounds include E-3-{1-[2-methyl-3-(1-imidazolylmethyl)]indolyl}-acrylic acid and E-3-{1-[2-methyl-3-(3-pyridylmethyl)]-indolyl} acrylic acid, respectively. Methods for preparing these compounds from known starting materials are provided.

REFERENCES:
patent: 4363912 (1982-12-01), Cross et al.

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