Inhibition of thromboxane synthetase formation and arachidonic a

Details Inhibition of thromboxane synthetase formation and arachidonic a Inhibition of thromboxane synthetase formation and arachidonic a

1979-04-16

1981-01-06

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

A61K 31415

Patent

active

042436710

ABSTRACT:
1-(3-Phenyl-2-propenyl)-1H-imidazole, and its hydrochloride salt have been found to be potent inhibitor of thromboxane synthetase and therefore an inhibitor of arachidonic acid-induced platelet aggregation and bronchoconstriction.

REFERENCES:
Tai et al. Biochem. and Biophys. Res. Commun., 80: 236-242 (1978).
Yoshimoto et al. Prostaglandins, 16, No. 4, 529-540 (1978).
Nijkamp et al. Europ. J. Pharmacoc., 44; 179-186 (1977).
Chemical Abstracts 83: 157710t (1975).
Moncada et al., Prostaglandins 13, No. 4; 611-618 (1977).

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