Inhibition of the proliferation of cells of the multiple...

Details Inhibition of the proliferation of cells of the multiple... Inhibition of the proliferation of cells of the multiple...

2006-07-18

2006-07-18

Allen, Marianne P. (Department: 1647)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

C530S324000, C530S325000, C530S326000, C514S002600

Reexamination Certificate

active

07078478

ABSTRACT:
Multiple myeloma is treated by deletion mutants of the gp130 protein of the IL-3 receptor. These mutants inhibit the binding of Hck tyrosine kinase and the growth of tumor cells, particularly myeloma cells.

REFERENCES:
patent: WO/96/09382 (1996-03-01), None
Wells, Addditivity of Mutational Effects in Proteins. Biochemistry 29:8509-8517 (1990).
Freshney Culture of Animal Cells, A Manual of Basic Technique, Alan R. Liss, Inc., New York (1983).
Dermer Another Anniversary for the War on Cancer. Bio/Technology vol. 12, No. 3 p. 320 (Mar. 1994).
Murakami, M. et al. “Critical Cytoplasmic Region of the Interleukin 6 Signal Transducer gp 130 is Conserved in the Cylokine Receptor Family,”PNAS USADec. 1991, pp. 11349-11353, vol. 88.

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