Inhibition of the degradation of connective tissue matrix protei

Details Inhibition of the degradation of connective tissue matrix protei Inhibition of the degradation of connective tissue matrix protei

1995-01-30

1997-07-29

Seidleck, James J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

A61K 3166

Patent

active

056522274

ABSTRACT:
Bis-phosphonates such as clodronate, etidronate, pamidronate and alendronate are found to inhibit the degradation of connective tissue matrix protein components in mammals, including humans, and therefore are useful in the therapeutic and prophylactic treatment of mammals against a variety of physiological and pathological connective tissue disorders or extracellular protein degradation disorders including wounds, burns, fractures, lesions, ulcers, cancer and metastasis progression in connective tissues, rheumatoid arthritis and other arthitides, periodontitis, peri-implantitis, cysts, root canal treatment, AIDS, ulceration of the cornea, gastric ulceration, aftae, trauma, acne, psoriasis, loosening of end-osseal hip-protheses.

REFERENCES:
patent: 4234645 (1980-11-01), Gunther et al.
patent: 5157027 (1992-10-01), Biller et al.
Teronen et al., Characterization of Interstitial Collagenases in in Jaw Cyst Wall, Scandinavian Journal of Dental Research, vol. 3, pp. 1-19 (1995).
Suomalainen, Interstitial Collagenases in Gingival Crevicular Fluid and Saliva in Periodontal Diseases, University of Helsinki, Finland, 1993.
Teronen et al, Identification and Characterization of Gelatinases/Type IV Collagenases in Jaw Cysts, Journal of Oral Pathology & Medicine, vol. 23, pp. 1-7, 1994.
Ingman et al, Multiple Forms of Gelatinases/Type IV Collagenases in Saliva and Gingival Crevicular Fluid of Periodontitis Patients, Journal of Clinical Periodontology, vol. 26, pp. 26-31, 1994.
Ingman et al, Collagenase, Gelatinase and Elastase Activities in Sulcular Fluid of Osseointegrated Implants and Natural Teeth, Journal of Clinical Periodontology, vol. 21, pp. 301-307, 1994.
Fleisch, Biophosphonates Pharmacology and Use in the Treatment of Tumour-Induced Hypercalcaemic and Metastatic Bone Disease, Drugs, vol. 42, No. 6, pp. 919-944, 1991.
Lauhio et al, In vivo Inhibition of Human Neutrophil Collagenase (MMP-8) Activity During Long-Term Combination Therapy of Doxycycline and Non-Steroidal Anti-Inflammatory Drugs (NSAID) in Acute Reactive Arthritis, Clin Exp Immunol, vol. 98, pp. 21-28, 1994.
Santavirta et al, Role of Mesenchymal Collagenase in the Loosening of Total Hip Prosthesis, Clinical Orthopaedics and Related Research, vol. 290, pp. 206-214, May 1993.
Sorsa et al, Partial Purification and Characterization of Latent Human Leukocyte Collagenase, Medical Biology, vol. 63, pp. 66-72, 1985.
Konttinen et al, Substrate Specificity and Activation Mechanisms of Collagenase from Human Rheumatoid Synovium, Matrix, vol. 11, pp. 395-403, 1991.
Suomalainen et al, Specificity of the Anticollagenase Action of Tetracyclines: Relevance to Their Anti-Inflammatory Potential, Antimicrobial Agents and Chemotherapy, vol. 36, No. 1, pp. 227-229, Jan. 1992.
Sorsa et al, Collagenase in Synovitis of Rheumatoid Arthritis, Seminars in Arthritis and Rheumatism, vol. 22, No. 1, pp. 44-53, Aug. 1992.
Birkedal-Hansen, Role of Matrix Metalloproteinases in Human Periodontal Diseases, J Periodontol, vol. 64, No. 5, pp. 474-484, May 1993.
Kowolik et al, The Effect of Dichloromethylene Bisphosphonate on Human Gingival Crevicular Neutrophil Myeloperoxidase Activity, Archs Oral Biol, vol. 35, pp. 201S-203S, 1990.
Vincenti et al, Using Inhibitors of Metalloproteinases to Treat Arthritis, Arthritis & Rheumatism, vol. 37, No. 8, pp. 1115-1126, Aug. 1994.
Birkedal-Hansen et al, Matrix Metalloproteinases: A Review, Critical Reviews in Oral Biology and Medicine, vol. 4, No. 2, pp. 197-250, 1993.
Felix et al, The Effect of Several Diphosphonates on Acid Phosphohydrolases and Other Lysosomal Enzymes, Biochimica et Biophysica Acta, pp. 429-438, 1976.
Fleisch, Bisphosphonates in Bone Disease, Stampfli & Co., Ltd., Graphic Enterprise, Bern, 1993.
Greenwald, Guidelines For Clinical Trial Design for Evaluation of MMP Inhibitors, Annals New York Academy of Sciences, pp. 273-279, (1994).
DE Clerck et al., Matrix Metalloproteinases and Their Inhibitors in Tumor Progression, Annals New York Academy of Sciences pp. 222-232, (1994).
Krane, Clinical Importance of Metalloproteinases and Their Inhibitors, Annals New York Academy of Sciences, pp. 1-21 (1994).
Sorsa et al., Effects of Tetracyclines on Neutrophil, Gingival, and Salivary Collagenases, Annals New York Academy of Sciences, pp. 112-131 (1994).

Affiliated with

Also associated with

Rating

Inhibition of the degradation of connective tissue matrix protei does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibition of the degradation of connective tissue matrix protei, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibition of the degradation of connective tissue matrix protei will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-633847