Inhibition of the cystic fibrosis transmembrane conductance...

Details Inhibition of the cystic fibrosis transmembrane conductance... Inhibition of the cystic fibrosis transmembrane conductance...

2007-12-04

2007-12-04

Wang, Shengjun (Department: 1617)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

Reexamination Certificate

active

10332945

ABSTRACT:
Fluorescein and derivatives have use in the treatment of a disease of a living animal body, including human, which disease is responsive to the inhibition of the cystic fibrosis transmembrane conductance regulator chloride channels, for instance polycystic kidney disease and secretory diarrhoea.

REFERENCES:
patent: 6331286 (2001-12-01), Dees et al.
patent: WO 96/18101 (1996-06-01), None
CAS registry No. 18472-87-2 Phloxine B.
Schultz et al. “Pharmacology of CFTR chloride channel activity,” Physiological Reviews, 1999, vol. 79, suppl. No. 1, pp. s109-s144.
Alcantara-Licudine et al. “Analysis of phloxine B and uranine in coffee by High-performance liquid chromatography and capillary zone electrophoresis after solid phase extraction cleanup,” J. Agric. Food Chem, 1998, vol. 46, pp. 1005-1011.
Bachmann et al., “Potent stimulation and inhibition of the CFTR CI current by phloxine B”British Journal of Pharmacology131:433-440 (2000).
Cai et al., “Inhibition of the human CFTR CI channel by the fluorescein derivative phloxine B”Journal of Physiology531:124-125 (Dec. 2000).
Kaplan et al., “The potential of rose Bengal treatment used in photodynamic therapy of tumors”Voprosy Onkologii45(5):557-559 (1999).

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