Inhibition of the 5-lipoxygenase pathway

Details Inhibition of the 5-lipoxygenase pathway Inhibition of the 5-lipoxygenase pathway

1987-09-22

1988-06-14

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546197, 546208, 546281, 548524, 548526, 548558, C07D21132, C07D40106, C07D29510

Patent

active

047513101

ABSTRACT:
Compounds having the formula ##STR1## wherein n is 0 or 1, R.sup.2 through R.sup.9 are H or C.sub.1-2 alkyl, and X is pyridyl or mono- or disubstituted phenyl are useful in the preparation of the compounds which inhibit the 5-lipoxygenase pathway.

REFERENCES:
patent: 3823239 (1974-07-01), Fox et al.
patent: 4064260 (1977-12-01), Cherkofsky et al.
patent: 4110460 (1978-08-01), Baetz et al.
patent: 4153706 (1979-05-01), Bender et al.
patent: 4175127 (1979-11-01), Bender et al.
patent: 4186205 (1980-01-01), Bender et al.
patent: 4263311 (1981-04-01), Bender et al.
patent: 4507481 (1985-03-01), Davidson et al.
Mohrle, H. et al., Arch. Pharm., 316, pp. 47-55, (1983).
Claxton, G. et al., J. Med. Chem., 17, 3, 364-367, (1974).
Chem. Abs. 11994q, vol. 82, p. 507, (1975).
Lantos et al., J. Med. Chem., 27, 72-75, (1984).
Lantos et al., U.S. Ser. No. 856,246, filed Apr. 28, 1986.
Bender et al., J. Med. Chem., 28, 1169-1177, (1985).
Kano, S., J. Pharm. Soc. Japan, 92, 1, 55-58, (1972).
Andreani, A. et al., Arch. Pharm., (Weinheim), 315, 451-456, (1982).
Schoberl, A. et al., Liebigs Ann. Chem., 742, 85-97, (1970).
Lee, M. H. et al., Biochemical Pharmacology, 24, 1175-1178, (1975).
Andreani, A. et al., Eur. J. Med. Chem., 19, 3, 219-222, (1984).
Koyama, K. et al., Oyo Yakura Pharmacometrics, 26, 6, 869-876, (1983).

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