Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-08-24
1999-04-20
Wax, Robert A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 6, 435 793, 436536, 436518, G01N 3353
Patent
active
058957472
ABSTRACT:
The Tax protein of Human T Cell Leukemia Virus Type 1 (HTLV-I) transcriptionally activated the HTLV-I promoter through binding sites for ATF, a family of cellular bZIP transcription factors. In this disclosure, it is reported that Tax dramatically increases the in vitro DNA binding activity of multiple ATF proteins. Tax also stimulates DNA binding of related bZIP proteins but does not affect the activity of proteins lacking a bZIP domain. The increased DNA binding activity occurs by a novel mechanism in which Tax promotes homodimerization in the absence of DNA. The elevated concentration of the bZIP homodimer results in increased DNA binding.
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Green Michael R.
Wagner Susanne
Longton Enrique D.
University of Massachusetts Medical Center
Wax Robert A.
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