Inhibition of Syk kinase expression

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S006120, C435S091100, C435S325000, C435S375000, C536S023100, C536S024500

Reexamination Certificate

active

10880612

ABSTRACT:
The present invention relates, in general, to Syk kinase and, in particular, to a method of inhibiting Syk kinase expression using small interfering RNA (siRNA).

REFERENCES:
patent: 6242427 (2001-06-01), Schreiber et al.
patent: 2003/0232364 (2003-12-01), Shaughnessy et al.
patent: 2004/0009523 (2004-01-01), Shaughnessy et al.
patent: 2004/0018522 (2004-01-01), Dangond et al.
patent: 2004/0028685 (2004-02-01), Kinch et al.
patent: 2004/0106156 (2004-06-01), Perez et al.
patent: 2004/0219575 (2004-11-01), Neuman et al.
patent: 2005/0112630 (2005-05-01), Shaughnessy et al.
patent: 2005/0130117 (2005-06-01), Davis et al.
patent: 2005/0147593 (2005-07-01), Kinch
patent: 2005/0153425 (2005-07-01), Xu et al.
patent: 2005/0153923 (2005-07-01), Kinch
patent: 2005/0245475 (2005-11-01), Khvorova et al.
patent: 2005/0246794 (2005-11-01), Khvorova et al.
patent: 2005/0267059 (2005-12-01), Beardsley et al.
patent: 2006/0003322 (2006-01-01), Bentwich
patent: 2006/0058255 (2006-03-01), Chen et al.
patent: 2006/0073474 (2006-04-01), Perez et al.
patent: 2006/0127385 (2006-06-01), Sarkar et al.
patent: 2006/0141493 (2006-06-01), West et al.
patent: 2006/0150262 (2006-07-01), Bienkowska et al.
patent: WO 02/44321 (2002-06-01), None
Stenton et al. Aeroxlized Syk Antisense Suppresses Syk Expression, Mediator Release from Macrophages, and Pulmonary Inflammation. J. Immunology 2ooo: vol. 164: 3790-3797. The American Association of Immunologists.
Hammond et al. Post-Transcriptional Gene Silencing by Double-Stranded RNA. Nature 2001, vol. 2: 110-119. MacMillan Magazines Ltd.
Takada and Aggarwal, “TNF, Activates Syk Protein Tyrosine Kinase Leading TNF-Induced MAPK Activation, NF-κB Activation, and Apoptosis”, The Journal of Immunology 173: 1066-1077 (2004).
Takada et al, “Hydrogen Peroxide Activates NF-κB through Tyrosine Phosphorylation of IκBα and Serine Phosphorylation of p65”, The Journal of Biological Chemistry 278(26):24233-24241 (2003).
Ulanova et al, “Syk tyrosine kinase participates in β1-integrin signaling and inflammatory responses in airway epithelial cells”, Am. J. Physiol. Lung Cell Mol. Physiol. 288:L497-L-507 (2005).
Stenton et al, “Inhibition of Allergic Inflammation in the Airways Using Aerosolized Antisense to Syk Kinase”, The Journal of Immunology 169:1028-1036 (2002).
Mammalian Gene Collection (MGC) Program Team, Contributed by Francis S. Collins, “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”, PNAS 99(26):16899-16903 (2002).
Rowley et al, “Molecular Cloning of Roden p72Syk”, The Journal of Biological Chemistry 270(21):12659-12664 (1995).
Law et al, “Molecular Cloning of Human Syk”, The Journal of Biological Chemistry 269(16):12310-12319 (1994).
Vickers et al, “Efficient Reduction of Target RNAs by Small Interfering RNA and RNase H-dependent Antisense Agents”, The Journal of Biological Chemistry 278(9):7108-7118 (2003).
Scherer and Rossi, “Approaches for the sequence-specific knockdown of mRNA”, Nature Biotechnology 21(12):1457-1465 (2003).
Kalota et al, “Progress in the Development of Nucleic Acid Therapeutics for Cancer”, Cancer Biology & Therapy 3(1):4-12 (2004).
Holen et al, “Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor”, Nucleic Acids Research 30(8):1757-1766 (2002).
Jarad et al, “Nucleic acid-based techniques for post-transcriptional regulation of molecular targets”, Current Opinion in Nephrology and Hypertension 12:415-421 (2003).
Patil et al, “DNA-based Therapeutics and DNA Delivery Systems: A Comprehensive Review”, The AAPS Journal 7(1) Article 9:E-61-E77 (2005).
Hu et al, “Relative gene-silencing efficiencies of small interfering RNAs targeting sense and antisense transcripts from the same genetic locus”, Nucleic Acids Research 32(15):4609-4617 (2004).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Inhibition of Syk kinase expression does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibition of Syk kinase expression, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibition of Syk kinase expression will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3837553

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.