Inhibition of smooth muscle cell proliferation by antistasin and

Details Inhibition of smooth muscle cell proliferation by antistasin and Inhibition of smooth muscle cell proliferation by antistasin and

1991-07-16

1995-01-31

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530350, 530858, C07K 710, C07K 1508, A61K 3702

Patent

active

053858859

ABSTRACT:
The present invention provides methods for inhibiting smooth muscle cell proliferation, particularly smooth muscle cells present in blood vessel walls. A compound capable of inhibiting blood factor Xa is administered to the smooth muscle cells in an amount effective to inhibit proliferation of the cells. The compound capable of inhibiting blood factor Xa is preferably antistasin or tick anticoagulant peptide (TAP). In other aspects the present invention provides methods for treating atherosclerotic lesions and atherosclerosis, and methods of treating narrowing of the lumen of a blood vessel wherein the narrowing is caused at least in part by hyperplasia of smooth muscle cells in the wall of the blood vessel.

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