Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1999-02-16
1999-11-16
Fonda, Kathleen K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 23, 514 25, 514 53, 514 61, 514 62, 536 111, 536 41, 536 172, 536 187, 536 53, 536 55, 536 551, 536 552, 424450, A61K 31715, A61K 9127, C07H 100
Patent
active
059858524
ABSTRACT:
This invention provides compositions for inhibiting the binding between two cells, one expressing P- or L-selectin on the surface and the other expressing the corresponding ligand. A covalently crosslinked lipid composition is prepared having saccharides and acidic group on separate lipids. The composition is then interposed between the cells so as to inhibit binding. Inhibition can be achieved at an effective oligosaccharide concentration as low as 10.sup.6 fold below that of the free saccharide. Since selectins are involved in recruiting cells to sites of injury, these composition scan be used to palliate certain inflammatory and immunological conditions.
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Bertozzi Caroline
Dasgupta Falguni
Nagy Jon O.
Spevak Wayne R.
Aston David J.
Fonda Kathleen K.
Mahoney John W.
Ross Pepi
The Regents of the University of California
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