Inhibition of selectin binding

Details Inhibition of selectin binding Inhibition of selectin binding

1997-02-28

1999-10-05

Fonda, Kathleen K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 42, 514 53, 514 54, 514 61, 435 71, 435 72, A61K 3170, G01N 3353

Patent

active

059624221

ABSTRACT:
This invention provides a system for inhibiting the binding between two cells, one expressing P- or L-selectin on the surface and the other expressing the corresponding ligand. A covalently crosslinked lipid composition is prepared having saccharides and acidic group on separate lipids. The composition is then interposed between the cells so as to inhibit binding. Inhibition can be achieved at an effective oligosaccharide concentration as low as 10.sup.6 fold below that of the free saccharide. Since selectins are involved in recruiting cells to sites of injury, this system can be used to palliate certain inflammatory and immunological conditions.

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