Inhibition of restenosis by ultraviolet radiation

Details Inhibition of restenosis by ultraviolet radiation Inhibition of restenosis by ultraviolet radiation

1990-10-10

1991-10-01

Pellegrino, Stephen C.

Surgery

Instruments

Light application

606 7, 606 15, 606 16, 128398, A61N 500

Patent

active

050530330

ABSTRACT:
Restenosis following angioplasty can be inhibited by reducing the proliferation of smooth muscle cells in the blood vessel walls at an angioplasty site, and such reduction in cell proliferation can be accomplished by irradiating the angioplasty site with radiation in the ultraviolet (UV) wavelength range. The ultraviolet radiation is preferably delivered via an optical fiber or other waveguide incorporated, for example, into a percutaneous catheter. In operation, the ultraviolet radiation kills smooth muscle cells at the site, thereby reducing the risk of restenosis, while minimizing damage to surrounding tissue.

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