Inhibition of Respiratory Syncytial virus-induced cell fusion by

Details Inhibition of Respiratory Syncytial virus-induced cell fusion by Inhibition of Respiratory Syncytial virus-induced cell fusion by

1983-08-08

1986-10-28

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514394, 514636, A61K 31405, A61K 31415, A61K 31155

Patent

active

046199420

ABSTRACT:
A number of aromatic mono- and bis-amidines are capable of blocking cell fusion induced by Respiratory Syncytial (RS) virus. Suitable amidino compounds include those selected from the group consisting of 1-4-di(4-amidinophenoxy)-2-butanol; bis(5-amidino-2-benzimidazolyl)methane; 1,2-bis(5-amidino-2-benzimidazolyl )ethane; 5-amidino-indole; 5-amidinobenzimidazole, 5-amidino-1-methylindole and 5-amidino-1-(4-amidinobenzyl)indole. The most powerful of the compounds, bis(5-amidino-2-benzimidazolyl)methane (BABIM), is able to achieve complete suppression of syncytium formation at a concentration of 1 .mu.M. Inhibition occurs in RS virus-infected Hep-2 cells as well as CV-1 cells. BABIM also causes a significant retardation of RS virus penetration, but does not interfere with adsorption. Addition of the amidines after the penetration of RS virus does not affect single cycle yields. The compounds may be used in the prophylactic control of RS virus in man.

REFERENCES:
Chemical Abstracts, 95: 330u (1981).
Tidwell et al., J. Med. Chem., vol. 21, No. 7, 1978, pp. 613-623.

Affiliated with

Also associated with

Rating

Inhibition of Respiratory Syncytial virus-induced cell fusion by does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibition of Respiratory Syncytial virus-induced cell fusion by, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibition of Respiratory Syncytial virus-induced cell fusion by will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1346750