Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-01-31
1993-09-14
Schenkman, Leonard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514557, 514763, A61K 31015, A61K 3119, A61K 3135
Patent
active
052449165
ABSTRACT:
The present invention relates to the use of posttranslational modification inhibitors, such as isoprenylation inhibitors, to inhibit activation of phagocyte NADPH oxidase and respiratory burst. Therapeutic compositions containing various inhibitors, and methods of using same, are also disclosed.
REFERENCES:
Curnutte, et al., J. Biol. Chem. 262: 6450-2 (1987).
Curnutte, et al., J. Biol. Chem. 262: 5563-5569 (1987).
Clark, J. Infect. Dis. 161: 1140-7 (1990).
Buss, et al., Mol. Cell. Biol. 11: 1523-1530 (1991).
Bokoch, et al., J. Cell. Biol. 106: 1927-1936 (1988).
Quinn, et al., Nature 342: 198-200 (1989).
Bokoch, et al., Science 254: 1794-6 (1991).
Gibbs, Cell 65: 1-4 (1991).
Knaus, et al., Science 254: 1512-1515 (1991).
Maltese, et al., J. Biol. Chem. 265: 2148-2155 (1990).
Maltese, FASEB 4: 3319-3328 (1990).
Hancock, et al., EMBO J. 10: 641.sub.]646 (1991).
Hancock, et al., Cell 57: 1167-1177 (1989).
Casey, et al., PNAS USA 86: 8323-8327 (1989).
Schafer, et al., Science 245: 379-384 (1989).
Jackson, et al., PNAS USA 87: 3042-3046 (1990).
Endo, et al., FEBS 72: 323-326 (1976).
Alberts, et al., PNAS USA 77: 3957-3961 (1985).
Elson, et al., Carcinogenesis 9: 331-2 (1988).
Crowell, et al., J. Biol. Chem. 266: 17679-17686 (1991).
Bingham Douglas A.
Fitting Thomas
Logan April C.
Schenkman Leonard
The Scripps Research Institute
LandOfFree
Inhibition of respiratory burst using posttranslational modifica does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Inhibition of respiratory burst using posttranslational modifica, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibition of respiratory burst using posttranslational modifica will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2026850