Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Heavy metal or compound thereof
Reexamination Certificate
2006-04-27
2010-06-01
Hartley, Michael G (Department: 1618)
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Heavy metal or compound thereof
C424S489000
Reexamination Certificate
active
07727559
ABSTRACT:
Methods and compositions useful for neuronal protection in retinal cells in vitro and the protection of mammalian cells from reactive oxygen species in vivo are provided. Ultrafine nano-size cerium oxide particles, less than 10 nanometers in diameter, have been provided to decrease reactive oxygen species (ROS) in retina tissue that generates large amounts of ROS. These reactive oxygen species (ROS) are involved in light-induced retina degeneration and age-related macular degeneration (AMD). Cerium oxide nanoparticles have been used to promote the lifespan of retinal neurons and protect the neurons from apoptosis induced by hydrogen peroxide in vitro and in vivo. The neuronal protection in retinal cells is achieved by decreasing generation of intracellular reactive oxygen species (ROS). Thus, cerium oxide particles are used to promote the longevity of retinal neurons in vitro and mammalian cells in vivo.
REFERENCES:
patent: 2003/0187077 (2003-10-01), Chane-Ching
patent: 2004/0241206 (2004-12-01), Ketelson et al.
patent: 2006/0150526 (2006-07-01), Ota et al.
Ming-Shyong Tsai, The Study of the synthesis of nano-grade cerium oxide powder, Materials Letters, 58, 2270-2274, 2004.
Sigma—Aldrich Hand Book (2002004, p. 400).
P. Moongkarndi, K. Nuttavut, S. Kalungka, O. Luanratana, N. Pongpan, N. Neungton, “Antiproliferation, antioxidation and induction of apoptosis byGarcinia mangostana(mangosteen) on SKBR3 human breast cancer cell line”, Journal of Ethno-Pharmacology, vol. 90, (2004) pp. 161-166.
T.H. Margrain, M. Boulton, J.Marshall, D.H. Sliney, “Do blue light filters confer protection against age-related macualar degeneration?”, Progress in Retinal and Eye Research, vol. 23 (2004), pp. 523-531.
D. Bailey, L. Chow, S. Merchant, S.C. Kuiry, S. Patil, S. Seal, and B. Rzigalinski, “Cerium Oxide Nanoparticles Extend Cell Longevity and Act as Free Radical Scavengers”, online, [retrieved on Apr. 24, 2006] Retrieved from: http://www.med.miami.edu.mnbws/Rzigalinksill ,.html.
Rzigalinski, Beverly Ann, et al., “Cerium oxide nanoparticles increase the lifespan of cultured brain cells and protect against free radical and mechanical trauma” FASEB Journal, vol. 17 No. 4-5 (Mar. 2003), Page Abstract No. 377.24 URL, XP008095016 & FASEB Meeting on Experimental Biology: Translating the Genome, San Diego, CA, USA, Apr. 11-15, 2003 ISSN: 0892-6638 *Abstract*.
Cook, et al., “Neuronal Damage Induced by Polychlorinated Biphenyls is Partically Reversed by Cerium Oxide Nanoparticles”[online] vol. 2003, 2003, XP008095032 Retreived from the Internet: URL:http://sfn.scholarone.com/itin2003/main/htm]?new—page—id=126&abstract—id=14513&p—num=669.13&is—tech=0> [retrieved on Aug. 5, 2008} *abstract*.
Tusnekawa, S., et al., “Lattice relaxation of monosize Ce02-x nanocrystalline particles” Applied Surface Science Elsevier Netherlands, vol. 152, No. 1-2, Nov. 1999, pp. 53-56, XP002491212 ISSN: 0169-4332 * p. 53, col. 1, paragraph 2- col. 2, parahraph 1 *.
Hooper, Claire, Y., et al., “New treatment in age-related macular degeneration” Clinical & Experimental Ophthalmology, Oct. 2003, pp. 376-391, XP002491214 ISSN: 1442-6404 * pp. 378-382*.
Chen Junping
McGinnis James F.
Patil Swanand
Seal Sudipta
Sezate Steve
Hartley Michael G
Law Offices of Brian S. Steinberger , P.A.
Morlin Joyce P.
Samala Jagadishwar R
Steinberger Brian S.
LandOfFree
Inhibition of reactive oxygen species and protection of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Inhibition of reactive oxygen species and protection of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibition of reactive oxygen species and protection of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4215953