Drug – bio-affecting and body treating compositions – Topical sun or radiation screening – or tanning preparations
Reexamination Certificate
2008-03-25
2008-03-25
Hartley, Michael G. (Department: 1618)
Drug, bio-affecting and body treating compositions
Topical sun or radiation screening, or tanning preparations
C424S401000, C424S489000
Reexamination Certificate
active
11796347
ABSTRACT:
Methods and compositions useful for neuronal protection in retinal cells in vitro and the protection of mammalian cells from reactive oxygen species in vivo are provided. Ultrafine nano-size cerium oxide particles, less than 10 nanometers in diameter, have been provided to decrease reactive oxygen species (ROS) in retina tissue that generates large amounts of ROS. These reactive oxygen species (ROS) are involved in light-induced retina degeneration and age-related macular degeneration (AMD). Cerium oxide nanoparticles have been used to promote the lifespan of retinal neurons and protect the neurons from apoptosis induced by hydrogen peroxide in vitro and in vivo. The neuronal protection in retinal cells is achieved by decreasing generation of intracellular reactive oxygen species (ROS). Thus, cerium oxide particles are used to promote the longevity of retinal neurons in vitro and mammalian cells in vivo.
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Chen Junping
McGinnis James F.
Patil Swanand
Seal Sudipta
Sezate Steve
Hartley Michael G.
Law Offices of Brian S. Steinberger , P.A.
Samala Jagadishwar
Steinberger Brian S.
University of Central Florida Research Foundation Inc.
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