Inhibition of reactive oxygen species and protection of...

Drug – bio-affecting and body treating compositions – Topical sun or radiation screening – or tanning preparations

Reexamination Certificate

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C424S401000, C424S489000

Reexamination Certificate

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07347987

ABSTRACT:
Methods and compositions useful for neuronal protection in retinal cells in vitro and the protection of mammalian cells from reactive oxygen species in vivo are provided. Ultrafine nano-size cerium oxide particles, less than 10 nanometers in diameter, have been provided to decrease reactive oxygen species (ROS) in retina tissue that generates large amounts of ROS. These reactive oxygen species (ROS) are involved in light-induced retina degeneration and age-related macular degeneration (AMD). Cerium oxide nanoparticles have been used to promote the lifespan of retinal neurons and protect the neurons from apoptosis induced by hydrogen peroxide in vitro and in vivo. The neuronal protection in retinal cells is achieved by decreasing generation of intracellular reactive oxygen species (ROS). Thus, cerium oxide particles are used to promote the longevity of retinal neurons in vitro and mammalian cells in vivo.

REFERENCES:
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T.H. Margrain, M. Boulton, J.Marshall, D.H. Sliney, “Do blue light filters confer protection against age-related macualar degeneration?”, Progress in Retinal and Eyé Research, vol. 23, (2004), pp. 523-531.
D. Bailey, L. Chow, S. Merchant, S.C. Kuiry, S. Patil, S. Seal, and B. Rzigalinski, “Cerium Oxide Nanoparticles Extend Cell Longevity and Act as Free Radical Scavengers”, online, [retrieved on Apr. 24, 2006] Retrieved from: http://www.med.miami.edu.mnbws/Rzigalinksi11,.html.

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