Drug – bio-affecting and body treating compositions – Fermentate of unknown chemical structure – Having a known elemental analysis
Patent
1975-11-17
1977-03-29
Rosen, Sam
Drug, bio-affecting and body treating compositions
Fermentate of unknown chemical structure
Having a known elemental analysis
195 18, 424317, A61K 3514, A61K 3119, C12B 300
Patent
active
040149935
ABSTRACT:
A process for inhibiting platelet aggregation by the addition of a member selected from the group consisting of a compound of the formula: ##STR1## WHEREIN IS PHENYL OR CYCLOHEXANE AND X and Y can be the same or different and are hydrogen, fluoro, chloro, bromo, alkyl of from 1 to 8 carbon atoms, inclusive or alkoxy of from 1 to 8 carbon atoms inclusive, and the pharmacologically acceptable salts thereof to in vivo and in vitro platelet systems. In vitro systems include whole blood as kept in blood banks, whole blood as used in heart-lung machines and platelet-rich concentrates. In vivo systems include human or animal bodies. The process provides a means for treating hemorrhage due to thrombocytopenia which in turn is caused by irradiation cancer chemotherapy or immunosuppressants as well as hemophilia due to cogenital defects.
REFERENCES:
gorog et al. J. Pharmacy & Pharmacology, vol. 22 (1970), pp. 86-92.
O'Brien-The Lancet, No. 7548(1), Apr. 1968, pp. 894-895.
Shen-Chem. Abst., vol. 69 (1968), p. 1552t.
Merck-Chem. Abst., vol. 66 (1967), p. 10765e.
Killinger John J.
Rosen Sam
Saliwanchik Roman
The Upjohn Company
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