Inhibition of platelet aggregation with selected phosphonic and

Details Inhibition of platelet aggregation with selected phosphonic and Inhibition of platelet aggregation with selected phosphonic and

1977-12-23

1979-04-10

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

424199, 424210, 424211, 424214, 424217, 424218, 424219, 424220, 424222, 424224, 195 18, A61K 3514, A61K 31685, A61K 3166

Patent

active

041488792

ABSTRACT:
A process for inhibiting platelet aggregation or thrombus formation by the addition of a member selected from the group consisting of a compound of the formula: ##STR1## WHEREIN X is an alkyl or alkenyl chain having 2-8 carbon atoms, one of which carbon atoms may be in the form of a carbonyl group, Y is H, alkyl, dialkylaminoethyl, aryl, aralkyl or aryl and aralkyl substituted with one or more R, and R is H, lower alkyl, lower alkoxy, halogen, CF.sub.3, NO.sub.2, OH, CN, COOR.sub.1, ##STR2## NHCOR.sub.1, NR.sub.1 R.sub.2 or ##STR3## where R.sub.1 and R.sub.2 are each selected from the group consisting of H and lower alkyl; R, R.sub.1 and R.sub.2 being the same or different, T is selected from the group consisting of O, NH, S and CH.sub.2 with the proviso that only one T is O, Z is 0 or 1 and n is 0-5; and pharmaceutically acceptable salts thereof, to in vivo and in vitro platelet systems.

REFERENCES:
patent: 3984501 (1976-10-01), Rajadhyaksha et al.
patent: 4016223 (1977-04-01), Rajadhyaksha et al.

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