Inhibition of platelet activation, aggregation and/or...

Surgery: light – thermal – and electrical application – Light – thermal – and electrical application – Thermal applicators

Reexamination Certificate

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C607S113000

Reexamination Certificate

active

07846193

ABSTRACT:
A method for treating acute coronary syndromes (i.e., unstable angina or non-Q-wave MI) or transient ischemic attacks in a human or animal patient by placing a heat exchange apparatus in the patient's vasculature and using that heat exchange apparatus to cool the patient to a temperature (e.g. 30-36° C.) at which platelet inhibition (i.e., inhibition of platelet activation and/or aggregation and/or adhesion) occurs. Anti-shivering drugs or anesthesia may be administered to patients whose body temperature is cooled below that patient's shivering threshold (typically approximately 35.5 C). If it is determined that platelet inhibition is no longer desirable, such as when the patient is about to undergo a surgical or interventional procedure wherein bleeding could be problematic, the hypothermia-induced platelet inhibition may be rapidly reversed by using the intravascular heat exchange apparatus to re-warm the patient's body to normothermia or near normothermia.

REFERENCES:
patent: 697181 (1902-04-01), Smith
patent: 5149676 (1992-09-01), Kim et al.
patent: 5174285 (1992-12-01), Fontenot
patent: 5344436 (1994-09-01), Fontenot et al.
patent: 5486208 (1996-01-01), Ginsburg
patent: 5957963 (1999-09-01), Dobakl, III
patent: 6096068 (2000-08-01), Dobak, III et al.
patent: 6126684 (2000-10-01), Gobin et al.
patent: 6149673 (2000-11-01), Ginsburg
patent: 6149676 (2000-11-01), Ginsburg
patent: 6527798 (2003-03-01), Ginsburg et al.
patent: 6544282 (2003-04-01), Dae et al.
patent: 6582398 (2003-06-01), Worthen et al.
patent: 6843800 (2005-01-01), Dobak, III
patent: PCTUS9918939 (1999-04-01), None
patent: PCTUS0020321 (2000-04-01), None
Watts, Dorraine Day. Hypothermic Coagulopathy in Trauma: Effect of Varying Levels of Hypothermia on Enzyme Speed, Platelet function and Fibrinolytic Activity. 1997. pp. 1-10.
Michelson et al., The effects of asprin and hypothermia on platelet function in vivo. British Journal od Haematology, 1999, 104, 64-68.
Frelinger et al., Combined Effects of Mild Hypothermia and Glycoprotein IIb/IIIa Antagonists on Platelet-Platelet and Leukocyte-Platelet Aggregation. The Americal Journal od Cardiology vol. 92 Nov. 1, 2003.
U.S. Appl. No. 60/181,249, Keller.
U.S. Appl. No. 09/138,830, Ginsburg, et al.
Michelson et al., The Effects of Aspirin and Hypothermia on Platelet Function in Vivo. British Journal of Haematology, 1999,104, 64-68.
Frelinger et al., Combined Effects of Mild Hypothermia and Glycoprotein IIb/IIIa Antagonists on Platelet-Platelet and Leukocyte-Platelet Aggregation. The American Journal of Cardiology, vol. 92, Nov. 1, 2003.

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