Inhibition of nuclear transcription factor NF-.kappa.B by caffei

Details Inhibition of nuclear transcription factor NF-.kappa.B by caffei Inhibition of nuclear transcription factor NF-.kappa.B by caffei

1997-09-05

1999-11-09

Witz, Jean C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514557, 560 75, A01N 3710, A01N 3700, C07C 6976

Patent

active

059815833

ABSTRACT:
The present invention is drawn to the inhibition of activation of NF-.kappa.B by caffeic acid phenethyl ester (CAPE) and two analogues of CAPE. Tumor necrosis factor (TNF) activation of NF-.kappa.B is completely blocked by CAPE in a dose- and time-dependent manner, as is activation by phorbol ester, ceramide, hydrogen peroxide, and okadaic acid. Additionally, capsaicin (8-methyl-N-vanillyl-6-noneamide) and resiniferatoxin inhibit the activation of NF-.kappa.B induced by different agents.

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patent: 5290816 (1994-03-01), Blumberg
patent: 5591773 (1997-01-01), Grunberger et al.
Deal et al. "Treatment of arthrtis with topical capsaicin: A double-blind trial," Clin. Ther. (1991) 13(3):383-395.
Natarajan et al. "Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-.kappa.B," Proc. Natl. Acad. Sci. USA (Aug. 1996) 93: 9090-5.
Singh et al. "Activation of transcription factor NK-.kappa.B is suppressed by curcumin (diferulolymethane)," J. Biol. Chem. (Oct. 1995) 270(42): 24995-25000.

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