Inhibition of noninactivating Na channels of mammalian optic ner

Details Inhibition of noninactivating Na channels of mammalian optic ner Inhibition of noninactivating Na channels of mammalian optic ner

1997-03-27

1999-07-13

Fay, Zohreh

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514912, A61K 31425

Patent

active

059227460

ABSTRACT:
A method and composition for altering a plausible sequence of pathological events in retinal ganglion cells associated with glaucoma, the sequence including membrane depolarization, influx of millimolar amounts of Na.sup.+ via non-inactivating Na.sup.+ channels, and the lethal elevation of cell Ca.sup.2+ due to reversal of the Na.sup.+ /Ca.sup.2+ exchanger. The method includes blocking, by administration of a selected composition, of associated, non-inactivating Na.sup.+ channels in retinal ganglion cells in order to limit Na.sup.+ /Ca.sup.+ exchange in the retinal ganglion cells and prevent buildup of the Ca.sup.2+ level in the retinal ganglion cells to a lethal level. The results in a method of preventing retinal ganglion cell death, associated with glaucoma, by administering to the optic nerve of a mammal, a compound which blocks the non-inactivating sodium ion channels of the optic nerve. Alternately, said invention relates to a method of preventing optic retinal ganglion cell death in a human by administering to the retinal ganglion cells of said human a compound which blocks the non-inactivating sodium ion channel of the retinal ganglion cells.

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