Inhibition of nitric oxide production by retinoic acid

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

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514825, 514895, 514903, A61K 3119

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active

054571294

ABSTRACT:
A novel method of inhibiting production of two important mediators of cellular function, tumor necrosis factor and nitric oxide, and treating a pathophysiological state characterized by an undesirable production or level of tumor necrosis factor or nitric acid. The methods of the present invention employ retinoic acid compounds. The most preferred retinoic acid is all-trans-retinoic acid.

REFERENCES:
patent: 5157046 (1992-10-01), Van Wauwe et al.
patent: 5264578 (1993-11-01), Chandraratna
Chemical Abstracts (114: 79814x) 1991.

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