Inhibition of neovascularization using VEGF-specific oligonucleo

Details Inhibition of neovascularization using VEGF-specific oligonucleo Inhibition of neovascularization using VEGF-specific oligonucleo

1995-07-12

1998-09-01

Campbell, Bruce R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 231, 536 245, 935 34, A61K 4800, C07H 2102, C07H 2104

Patent

active

058011560

ABSTRACT:
Disclosed are methods of reducing neovascularization and of treating various disorders associated with neovascularization. These methods include administering to a tissue or subject a synthetic oligonucleotide specific for vascular endothelial growth factor nucleic acid effective in inhibiting the expression of vascular endothelial growth factor.

REFERENCES:
patent: 5585479 (1996-12-01), Hoke et al.
Monacci et al. (1993) American Journal of Physiology 264:c995-c1002.
Garrido et al. (1993) Growth Factors 8:109-117.
Uhlmann et al. (1990) Chemical Reviews 90:543-584.
Uchida et al., (1995) Antisense Res. & Dev. 5(1):87 (Abstract OP-10).
Nomura et al., (1995) Antisense Res. & Dev. 5(1):91 (Abstract OP-18).
Pierce et al. (1995) Investigative Ophthalmology & Visual Science 36:Abstract 3990.
Smith et al. (1995) Investigative Ophthalmology & Visual Science 36:Abstract 3992.
Detmar et al. (1995) Journal of Investigative Dermatology 105:44-50.
Brown et al. (1995) Journal of Investigative Dermatology 104:744-749.
Monia et al. (1993) Journal of Biological Chemistry 268:14514-14522.
Uhlmann et al. (1990) Chemical Reviews 90:543-584.
Detmar et al. (1994) Journal of Experimental Medicine 180:1141-1146.
R. Weiss (1991) Science 139: 108-109.
R. W. Wagner (1994) Nature 372: 333-335.
S. Wu-Pong (1994) Pharmaceutical Technology, 18: 102-114.
Stein et al (1993) Science 261: 1004-1012.
Stull et al. (995) Pharmaceutical Research 12: 465-483.
Y. Rojanasakul (1996) Advanced Drug Delivery Reviews 18: 115-131.
Milligan et al J. Medicinal Chemistry 36: 1923-1937.

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