Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2008-04-07
2010-12-14
Goddard, Laura B (Department: 1642)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C435S375000
Reexamination Certificate
active
07851436
ABSTRACT:
The present invention provides combinations and methods for inducing cell death, inhibiting angiogenesis, and inhibiting cell migration. In particular, the present invention provides methods for inducing cell death in a cell expressing an αvβ3 and/or an αvβ5 integrin.
REFERENCES:
patent: 5399347 (1995-03-01), Trentham et al.
patent: 5466468 (1995-11-01), Schneider et al.
Zhu et al, J Cell Biology, 1999, 144:1069-1080.
Zips et al. (2005, In Vivo, 19:1-7).
Christiansen et al (Mol Cancer Ther, 2004, 3:1493-1501).
Topp et al (Journal of Controlled Release, 1998, 53:15-23).
Bowie et al (Science, 1990, 247:1306-1310).
Tandon et al (JK Science, Apr.-Jun. 2005, vol. 7, p. 61-62).
Wilder (Ann Rheum Dis, 2002, 61(Suppl II):ii96-ii99).
Achilefu et al, Synergistic effects of light-emitting probes and peptides for targeting and monitoring integrin expression, PNAS, 2005, pp. 7976-7981, vol. 102, No. 22.
Ackley et al, Oligomerization-dependent Regulation of Motility and Morphogenesis by the Collagen XVIII NC1/Endostatin Domain, J. Cell Biology, 2001, pp. 1233-1246, vol. 152, No. 6.
Altschul et al, Basic Local Alignment Search Tool, J. Mol. Biol., 1990, pp. 403-410, vol. 215.
Altschul et al, Gapped BLAST and PSI-BLAST: a new generation of protein database search programs, Nucleic Acids Research, 1997, pp. 3389-3402, vol. 25, No. 17.
Brem et al, Inhibition of Tumor Angiogenesis Mediated by Cartilage, J. of Exp. Med., 1975, pp. 427-439, vol. 141.
Brooks et al, Integrin avβ3 Antagonists Promote Tumor Regression by Inducing Apoptosis of Angiogenic Blood Vessels, Cell, 1994, pp. 1157-1164, vol. 79.
Chansky et al, Expression of Cartilage Extracellular Matrix and Potential Regulatory Genes in a New Human Chondrosarcoma Cell Line, J. Orthop. Res., 1998, pp. 521-530, vol. 16, No. 5.
Darland et al, Blood vessel maturation: vascular development comes of age, J. Clin. Invest., 1999, pp. 157-158, vol. 103, No. 2.
Dell et al, The Role of PDGF Receptor Inhibitors and PI3-Kinase Signaling in the Pathogenesis of Corneal Neovascularization, Invest. Ophthalmol. Vis. Sci., 2006, pp. 1928-1937, vol. 47.
Eisenstein et al, The Resistance of Certain Tissues to Invasion, Am. J. Pathol., 1973, pp. 765-774, vol. 73.
Friedlander et al, Involvement of integrins avβ3 and avβ5 in ocular neovascular diseases, PNAS, 1996, pp. 9764-9769, vol. 93.
Hayami et al, Specific loss of chondromodulin-I gene expression in chondrosarcoma and the suppression of tumor angiogenesis and growth by its recombinant protein in vivo, FEBS Letters, 1999, pp. 436-440, vol. 458.
Karlin et al, Methods for assessing the statistical significance of molecular sequence features by using general scoring schemes, PNAS, pp. 2264-2268, vol. 87.
Kenyon et al, A Model of Angiogenesis in the Mouse Cornea, Invest. Ophthalmol. Vis. Sci., 1996, pp. 1625-1632, vol. 37, No. 8.
Kruger et al, Protein Binding Alters the Activity of Suramin, Carboxyamidotriazole, and UCN-01 in an ex Vivo Rat Aortic Ring Angiogenesis Assay, Clin. Can. Res., 2001, pp. 1867-1872, vol. 7.
Kusafuka et al, Cartilage-specific matrix protein, chondromodulin-I (ChM-I), is a strong angio-inhibitor in endochondral ossification of human neonatal vertebral tissues in vivo: relationship with angiogenic factors in the cartilage, ACTA Histochem., 2002, pp. 167-175, vol. 104, No. 2.
Kyriakides et al, The Distribution of the Matricellular Protein Thrombospondin 2 in Tissues of Embryonic and Adult Mice, J. Histochem. Cytochem., 1998, pp. 1007-1015, vol. 46, No. 9.
Langer et al, Isolation of a Cartilage Factor That Inhibits Tumor Neovascularization, Science, pp. 70-71, vol. 193, 1976.
Maeshima et al, Tumstatin, an Endothelial Cell-Specific Inhibitor of Protein Synthesis, Science, 2002, pp. 140-143, vol. 295.
Maubant et al, Blockade of avβ3 and avβ5 integrins by RGD mimetics induces anoikis and not integrin-mediated death in human endothelial cells, Blood, pp. 3035-3044, vol. 108, 2006.
McAlinden et al, α-Helical Coiled-coil Oligomerization Domains Are Almost Ubiquitous in the Collagen Superfamily, J. Biol. Chem., 2003, pp. 42200-42207, vol. 278, No. 43.
McAlinden et al, Trimerization of the Amino Propeptide of Type IIA Procollagen Using a 14-Amino Acid Sequence Derived from the Coiled-Coil Neck Domain of Surfactant Protein D, J. Biol. Chem., 2002, pp. 41274-41281, vol. 277, No. 43.
Moses et al, Troponin I is present in human cartilage and inhibits angiogenesis, PNAS, 1999, pp. 2645-2650, vol. 96.
Nyberg et al, Endogenous Inhibitors of Angiogenesis, Cancer Res., 2005, pp. 3967-3979, vol. 65, No. 10.
Oganesian et al, Type IIA Procollagen Amino Propeptide Is Localized in Human Embryonic Tissues, J. Histochem. Cytochem., 1997, pp. 1469-1480, vol. 45, No. 11.
Passaniti et al, A Simple, Quantitative Method for Assessing Angiogenesis and Antiangiogenic Agents Using Reconstituted Basement Membrane, Heparin, and Fibroblast Growth Factor, Laboratory Investigation, 1992, pp. 519-528, vol. 67, No. 4.
Prockop et al, Procollagen N-Proteinase and Procollagen C-Proteinase. Two Unusual Metalloproteinases that are Essential for Procollagen Processing Probably Have Important Roles in Development and Cell Signaling, Matrix Biology, 1997, pp. 399-408, vol. 16.
Reardon et al, Localization of pN-type IIA procollagen on adult bovine vitreous collagen fibrils, Matrix Biology, 2000, pp. 169-173, vol. 19.
Ryan et al, Differential Expression of a Cysteine-rich Domain in the Amino-terminal Propeptide of Type II (Cartilage) Procollagen by Alternative Splicing of mRNA, J. Biol. Chem., 1990, pp. 10334-10339, vol. 265, No. 18.
Sandell et al, Alternative Splice Form of Type II Procollagen mRNA (IIA) Is Predominant in Skeletal Precursors and Non-Cartilaginous Tissues During Early Mouse Development, Develop. Dyn., 1994, pp. 129-140, vol. 199.
Seo et al, TIMP-2 Mediated Inhibition of Angiogenesis: An MMP-Independent Mechanism, Cell, 2003, pp. 171-180, vol. 114.
Stupack et al, Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins, J. Cell Biol., 2001, pp. 459-470, vol. 155, No. 3.
Teitelbaum, Osteoclasts, integrins, and osteoporosis, J. Bone Miner. Metab., 2000, pp. 344-349, vol. 18.
Thorogood et al, Transient Expression of Collagen Type II at Epitheliomesenchymal Interfaces during Morphogenesis of the Cartilaginous Neurocranium, Develop. Biol., 1986, pp. 497-509, vol. 116.
Wang et al, Regulation of Adenovirus Membrane Penetration by the Cytoplasmic Tail of Integrin β5, J. Virology, 2000, pp. 2731-2739, vol. 74, No. 6.
Wang et al, Annexin V/β5 Integrin Interactions Regulate Apoptosis of Growth Plate Chondrocytes, J. Biol. Chem., 2006, pp. 30848-30856, vol. 281, No. 41.
Wu et al, Inhibition of corneal angiogenesis by local application of vasostatin, Molecular Vision, 2005, pp. 28-35, vol. 11.
Ye et al, Design, Synthesis, and Evaluation of Near Infrared Fluorescent Multimeric RGD Peptides for Targeting Tumors, J. Medicinal Chemistry, 2006, pp. 2268-2275, vol. 49, No. 7.
Zhu et al, Type IIA Procollagen Containing the Cysteine-rich Amino Propeptide Is Deposited in the Extracellular Matrix of Prechondrogenic Tissue and Binds to TGF-β1 and BMP-2, J. Cell Biol., 1999, pp. 1069-1080, vol. 144, No. 5.
Sandell Linda
Wang Zhepeng
Goddard Laura B
Polsinelli Shughart PC
Washington University
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