Inhibition of matrix metalloproteases by substituted biaryl...

Details Inhibition of matrix metalloproteases by substituted biaryl... Inhibition of matrix metalloproteases by substituted biaryl...

2005-06-28

2005-06-28

Richter, Johann (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S287000

Reexamination Certificate

active

06911449

ABSTRACT:
Matrix metalloprotease inhibiting compounds, pharmaceutical compositions thereof and a method of disease treatment using such compounds are presented. The compounds of the invention have the generalized formulas:wherein r is 0-2, T is selected fromand R40is a mono- or bi-heterocyclic structure.These compounds are useful for inhibiting matrix metalloproteases and, therefore, combating conditions to which MMP's contribute, such as osteoarthritis, rheumatoid arthritis, septic arthritis, periodontal disease, corneal ulceration, proteinuria, aneurysmal aortic disease, dystrophobic epidermolysis, bullosa, conditions leading to inflammatory responses, osteopenias mediated by MMP activity, tempero mandibular joint disease, demyelating diseases of the nervous system, tumor metastasis or degenerative cartilage loss following traumatic joint injury, and coronary thrombosis from athrosclerotic plaque rupture. The present invention also provides pharmaceutical compositions and methods for treating such conditions.

REFERENCES:
patent: 5925637 (1999-07-01), VanZandt et al.
patent: 6225314 (2001-05-01), VanZandt et al.
H. Birkedal-Hansen et al., Matrix Metalloproteinases: A Review, Critical Reviews in Oral Biology and Medicine, 4(2): 197-250 (1993).

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