Inhibition of matrix metalloproteases by 2-(.omega.-arolalkyl)-4

Details Inhibition of matrix metalloproteases by 2-(.omega.-arolalkyl)-4 Inhibition of matrix metalloproteases by 2-(.omega.-arolalkyl)-4

1997-05-15

1999-08-03

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562434, 562429, 514561, 514568, 514569, C07C 5976

Patent

active

059327634

ABSTRACT:
The present invention provides pharmaceutical compositions and methods for treating certain conditions comprising administering an amount of a compound or composition of the invention which is effective to inhibit the activity of at least one matrix metalloprotease, resulting in achievement of the desired effect. The compounds of the present invention are of the generalized formula ##STR1## where v is 1, 2, 3 or 4 and Ar represents a substituted aromatic moiety. These compounds are useful for inhibiting matrix metalloproteases and, therefore, combating conditions to which MMP's contribute, such as osteoarthritis, rheumatoid arthritis, septic arthritis, periodontal disease, corneal ulceration, proteinuria, aneurysmal aortic disease, dystrophobic epidermolysis, bullosa, conditions leading to inflammatory responses, osteopenias mediated by MMP activity, tempero mandibular joint disease, demyelating diseases of the nervous system, tumor metastasis or degenerative cartilage loss following traumatic joint injury, and coronary thrombosis from atherosclerotic plaque rupture. The present invention also provides pharmaceutical compositions and methods for treating such conditions.

REFERENCES:
patent: 4337267 (1982-06-01), Eistetter et al.

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