Inhibition of mammalian collagenolytic enzymes by tetracyclines

Details Inhibition of mammalian collagenolytic enzymes by tetracyclines Inhibition of mammalian collagenolytic enzymes by tetracyclines

1983-12-29

1987-05-19

Meyers, Albert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

3,10-dihydroxy-2-naphthacene carboxamide or derivative doai

A61K 3165

Patent

active

046668977

ABSTRACT:
A method of reducing pathologically excessive levels of activity of collagenolytic enzymes in mammals to substantially normal levels by administering 10-100% of the normal antibiotic therapeutic dose of a tetracycline is disclosed.

REFERENCES:
patent: 2895880 (1959-07-01), Rosenthal
patent: 4248892 (1981-02-01), Kanamaru et al.
patent: 4371465 (1983-02-01), McGregor
patent: 4457936 (1984-07-01), Draeger et al.
Bauer, et al., 1983, J. Invest. Dermatol., vol. 81, pp. 162, 163 168.
Harris, et al., 1984, Collagen Rel. Res., vol. 4, p. 493.
Berman and Manabe, 1973, Ann. Ophthalmol., Nov., p. 1193.
Golub, et al., 1985, J. Periodontal Res., vol. 20, pp. 12-23.
Welgus and Stricklin, 1983, J. Biol. Chem., vol. 258, p. 12259.
Uitto, et al., 1984, J. Oral. Path., vol. 13, p. 412.
Narayanan and Page., 1983, Collagen Rel. Res., vol. 3, p. 54.
Golub, et al., 1985, J. Periodontal. Res., Special Issue, p. 93.
Vater, et al., 1978, J. Clin. Invest., vol. 62, p. 987.
Harris, et al., 1984, Collagen Rel. Res., vol. 4, pp. 504-505.
Cowen, et al., 1985, Biochem. International, vol. 11, p. 273.
Belaisse, et al., 1985, Biochem. Biophys. Res. Commun., vol. 133, p. 483.
Golub, et al., 1983, J. Periodontal Res., vol. 18, pp. 516-526.
Chemical Abstracts 100:96203a (1983).
Chemical Abstracts, 93:142977t (1980).
Chemical Abstracts, 76:30596k (1969).
Dreisbach et al., Induction of Collagenase Production in Vibrio B-30, J. Bacterial, vol. 135, No. 2 (1978) pp. 521-527.
Goodman and Gilman, The Pharmacological Basis of Therapeutics, 6th ed., pp. 961-962 (1980).

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