Inhibition of Mac-1 receptor binding to fibrinogen using D.sub.3

Details Inhibition of Mac-1 receptor binding to fibrinogen using D.sub.3 Inhibition of Mac-1 receptor binding to fibrinogen using D.sub.3

1991-07-18

1995-12-05

Woodward, Michael P.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530350, 530326, 530327, 530328, C07K 1475, C07K 706

Patent

active

054730511

ABSTRACT:
The present invention contemplates therapeutic compositions containing a D.sub.30 homolog capable of binding to the Mac-1 receptor D.sub.30 binding site and inhibiting fibrinogen binding to the Mac-1 receptor via the D.sub.30 binding site, Methods of inhibiting Mac-1 receptor binding to any Mac-1 ligand and methods of inhibiting Mac-1 receptor mediated inflammation within a patient by administering a D.sub.30 homolog are also contemplated,

REFERENCES:
patent: 4650678 (1987-03-01), Fuhge et al.
Furlan et al., Biochim. et Biophys. Acta., 400:95-111 (1975).
Doolittle et al., Nature, 280:464-468 (1979).
Fair et al., J. Biol. Chem., 256:8018-8023 (1981).
Altieri et al., J. Clin. Invest., 78:968-976 (1986).
Price et al., J. Immunol., 139:4174-4177 (1987).
Altieri et al., J. Cell. Biol., 107:1893-1900 (1988).

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