Inhibition of lactate oxidase

Details Inhibition of lactate oxidase Inhibition of lactate oxidase

1980-04-17

1982-03-30

Wiseman, Thomas

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving oxidoreductase

435 28, 435184, 435190, 435805, C12Q 126, C12N 999

Patent

active

043224962

ABSTRACT:
Inhibition of lactate oxidase and an enzymatic analysis of an aqueous liquid containing lactate or lactic acid for an analyte other than lactate or lactic acid are disclosed. Undesired lactate oxidase activity, if any, in an enzymatic reagent composition, is inhibited by a lactate oxidase inhibitor selected from glyoxalic acid, oxalic acid, glycolic acid, and salts thereof. Preferred enzymatic analyses are performed in the presence of a lactate oxidase inhibitor with an enzymatic reagent composition producing hydrogen peroxide as a detectable species.

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Ghisla et al., "Mechanism of Inactivation of the Flavoenzyme Lactate Oxidase by Oxalate", J. Biol. Chem., vol. 250, No. 2, (1975), pp. 577-584.
Ghisla et al., "Studies on the Mechanism of Action of the Flavoenzyme Lactate Oxidase", J. Biol. Chem., vol. 252, No. 19, (1977), pp. 6729-6735.
Barman, Enzyme Handbook, vol. 1, Springer-Verlag, New York Inc., N.Y., (1969), p. 111.

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