Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1996-03-15
1999-09-07
Tsang, Cecilia J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 14, 514 15, 514 16, 530326, 530327, 530328, 530329, A61K 3800, A61K 3808, A61K 3810
Patent
active
059487658
ABSTRACT:
Compositions and methods for inhibition of the intracellular activation of a signal transducing protein comprising phosphoserine containing peptides derived from the Raf-1 protein are disclosed. The peptides bind to 14-3-3 protein and thereby prevent its association with the signal transducing peptide to block signal transduction. Also provided is an assay method for identifying a pharmacologic agent that can bind 14-3-3 protein and block signal transduction.
REFERENCES:
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Muslin Anthony J.
Shaw Andrey S.
Borin Michael
Tsang Cecilia J.
Washington University
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