Inhibition of insulin-induced adiposis

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514294, A01N 4342

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active

054968313

ABSTRACT:
The invention features methods of treating insulin-induced obesity, weight gain, and other conditions associated with hyperinsulinemia.

REFERENCES:
patent: 5247076 (1993-09-01), Goulet et al.
patent: 5252732 (1993-10-01), Sinclair et al.
patent: 5258389 (1993-11-01), Goulet et al.
Agras, Chapter III, Scientific American, Rubenstein et al., (eds.) New York, 1978, pp. 1-14.
Albers et al., FKPB-Rapamycin Inhibits a Cyclin-dependent Kinase Activity and a Cyclin D1-Cdk Association in Early G1 of an Osteosarcoma Cell Line, J. Biol. Chem. 268:22825-22829, 1993.
Alexander et al., Insulin Regulation of Protein Biosynthesis in Differentiated 3T3 Adipocytes, J. Biol. Chem. 260:11978-11985, 1985.
Alexander, et al., Tissue Specific Regulation of the Glyceraldehyde-3-phosphate Dehydrogenase Gene by . . . of 3T3 Adipocytes, UCLA Symposia on Molecular and Cellular Biology (New York: Liss, Inc), pp. 247-261, 1990.
Alexander et al., Insulin Stimulates Glyceraldehyde-3-phosphate Dehydrogenase Gene Expression Through Cis-acting DNA Sequences, Proc. Natl. Acad. Sci. USA 85:5092-5096, 1988.
Arroyo and Raychaudhuri, Retinoblastoma-repression of E2F-dependent Transcription Depends on the Ability of . . . with E2F and is Abrogated by the Adenovirus E1A Oncoprotein, Nucleic Acids Research 20:5947-5954, 1992.
Bagchi et al., The Retinoblastoma Protein Copurifies with E2F-1, an E1A-Regulated Inhibitor of the Transcription Factor E2F, Cell 65:1063-1072, 1991.
Cherington, Rapamycin Suppression of Murine Adipocyte Differentation: Okadaic Acid Counteracts a Subset of Rapamycin . . . Differentiation-Dependent Events, J. Cell. Biochem. Suppl. 0 (18 Part A) 1994, p. 160.
Bandara et al, Adenovirus E1a Prevents the Retinoblastoma Gene Product from Complexing with a Cellular Transcription Factor, Nature 351:494-497, 1991.
Berger et al., Decreased Expression of the Insulin-responsive Glucose Transporter in Diabetes and Fasting, Nature 340:70-72, 1989.
Cao et al., Independent Binding of the Retinoblastoma Protein and p107 to the Transcription Factor E2F, Nature 355:176-179, 1992.
Cao et al., Identification and Characterization of the Egr-1 Gene Product, a DNA-Binding Zinc Finger Protein Induced by Differentiation and Growth Signals, Mol. Cell. Biol. 10:1931-1939, 1990.
Charron and Kahn, Divergent Molecular Mechanisms for Insulin-resistant Glucose Transport in Muscle and Adipose Cells in Vivo, J. Biol. Chem. 265:7994-8000, 1990.
Chellappan et al., Adenovirus E1A, Simian Virus 40 Tumor Antigen, and Human Papillomavirus E7 Protein Share . . . Factor E2F and the Retinoblastoma Gene Product, Proc. Natl. Acad. Sci. USA 89:4549-4553, 1992.
Chellappan et al., The E2F Transcription Factor is a Cellular Target for the RB Protein, Cell 65:1053-1061, 1991.
Chittenden et al., The T/E1A-Binding Domain of the Retinoblastoma Product can Interact Selectively with a Sequence-Specific DNA-Binding Protein, Cell 65:1073-1082, 1991.
Christy and Nathans, Functional Serum Response Elements Upstream of the Growth Factor-Inducible Gene zif268, Mol. Cell. Biol. 9:4889-4895, 1989.
Clarke et al., Requirement for a Functional Rb-1 Gene in Murine Development, Nature 359:328-333, 1992.
DeCaprio et al. SV40 Large Tumor Antigen Forms a Specific Complex with the Product of the Retinoblastoma Susceptibility Gene, Cell 54:275-283, 1988.
Devoto et al., A Cyclin A-Protein Kinase Complex Possesses Sequence-Specific DNA Binding Activity: p33.sup.cdk2 is a Component of the E2F-Cyclin A Complex, Cell 68:167-176, 1992.
Dowdy et al., Physical Interaction of the Retinoblastoma Protein with Human D Cyclins, Cell 73:499-511, 1993.
Ewen et al., An N-Terminal Transformation-Governing Sequence of SV40 Large T Antigen Contributes to the Binding of Both p110.sup.Rb and a Second Cellular Protein, p120, Cell 58:257-267, 1989.
Ewen et al., Functional Interactions of the Retinoblastoma Protein with Mammalian D-type Cyclins, Cell 73:487-497, 1993.
Fingar et al., Dissociation of pp70 Ribosomal Protein S6 Kinase from Insulin-stimulated Glucose Transport in 3T3-L1 Adipocytes, J. Biol. Chem. 268:3005-3008, 1993.
Flemington et al., E2F-1-mediated Transactivation is Inhibited by Complex Formation with the Retinoblastoma Susceptibility Gene Product, Proc. Natl. Acad. Sci. USA 90:6914-6918, 1993.
Garvey et al., Pretranslational Suppression of an Insulin-Responsive Glucose Transporter in Rats with Diabetes Mellitus, Science 245:60-63, 1989.
Gerrits et al., Regulation of the GLUT4/Muscle-fat Glucose Transporter mRNA in Adipose Tissue of Insulin-deficient Diabetic Rats, J. Biol. Chem. 268:640-644, 1993.
Gilman et al., Multiple Protein-Binding Sites in the 5'-Flanking Region Regulate c-fos Expression, Mol. Cell. Biol. 6:4305-4316, 1986.
Girling et al., A New Component of the Transcription Factor DRTF1/E2F, Nature 362:83-87, 1993.
Gorski et al., Tissue-Specific In Vitro Transcription from the Mouse Albumin Promoter, Cell 47:767-776, 1986.
Greenberg et al., Effect of Protein Synthesis Inhibitors on Growth Factor Activation of c-fos, c-myc, and Actin Gene Transcription, Mol. Cell. Biol. 6:1050-1057, 1986.
Helin et al., A cDNA Encoding a pRB-Binding Protein with Properties of the Transcription Factor E2F, Cell 70:337-350, 1992.
Hiebert, Regions of the Retinoblastoma Gene Product Required for Its Interaction with the E2F Transcription Factor are Necessary for E2 . . . pRb-Mediated Growth Suppression, Mol. Cell. Biol. 13:3384-3391, 1993.
Hill et al., Functional Analysis of a Growth Factor-Responsive Transcription Factor Complex, Cell 73:395-406, 1993.
Hinds et al., Regulation of Retinoblastoma Protein Functions by Ectopic Expression of Human Cyclins, Cell 70:993-1006, 1992.
Huang et al., Two Distinct and Frequently Mutated Regions of Retinoblastoma Protein are Required for Binding to SV40 T Antigen, EMBO J. 9:1815-1822, 1990.
Huber et al., Transcription Factor E2F Binds DNA as a Heterodimer, Proc. Natl. Acad. Sci. USA 90:3525-3529, 1993.
Jacks et al., Effects of an Rb Mutation in the Mouse, Nature 359:295-302, 1992.
Kaelin et al., Definition of the Minimal Simian Virus 40 Large T Antigen- and Adenovirus E1A-Binding Domain in the Retinoblastoma Gene Product, Mol. Cell. Biol. 10:3761-3769, 1990.
Kahn, Facilitative Glucose Transporters: Regulatory Mechanisms and Dysregulation in Diabetes, J. Clin. Invest. 89:1367-1374, 1992.
Kahn et al., Differential Regulation of Two Glucose Transporters in Adipose Cells from Diabetic and Insulin-treated Diabetic Rats, J. Clin. Invest. 84:404-411, 1989.
Kato et al., Direct Binding of Cyclin D to the Retinoblastoma Gene Product (pRb) and pRb Phosphorylation by the Cyclin D-dependent Kinase CDK4, Genes & Development 7:331-342, 1993.
Krek et al., Binding to DNA and the Retinoblastoma Gene Product Promoted by Complex Formation of Different E2F Family Members, Science 262:1557-1560, 1993.
Lee et al., Mice Deficient for Rb are Nonviable and Show Defects in Neurogenesis and Haematopoiesis, Nature 359:288-294, 1992.
Lees et al., The Retinoblastoma Protein Binds to a Family of E2F Transcription Factors, Mol. Cell. Biol. 13:7813-7825, 1993.
Liu et al., Expression and Regulation of the Human GLUT4/Muscle-Fat Facilitative Glucose Transporter Gene in Transgenic Mice, J. Biol. Chem. 267:11673-11676, 1992.
Marais, et al., The SRF Accessory Protein Elk-1 Contains a Growth Factor-Regulated Transcriptional Activation Domain, Cell 73:381-393, 1993.
McClain et al., Dissection of the Growth versus Metabolic Effects of Insulin and Insulin-like Growth Factor-I in Transfected Cells Expressing Kinase-defective Human Insulin Receptors, J. Biol. Chem. 265:1678-82, 1990.
Morice et al., Rapamycin Inhibition of Interleukin-2-dependent p33.sup.cdk2 and p34.sup.cdc2 Kinase Activation in T Lymphocytes, J. Biol. Chem. 268:22737-22745, 1993.
Mudryj et al., Cell Cycle Regulation of the E2F Transcription Factor Involves an Interaction with Cyclin A, Cell 65:1243-1253, 1991.
Mudryj et al., A Role for the Adenovirus Inducible E2F Transcription Factor in a Proliferation Dependent Signal Transduction Pathway, EMBO J. 9:2179-2184, 1990.
Nasrin et al., An Insulin Response Element in the Glyceraldehyde

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