Inhibition of influenza virus replication by oligonucleotide pho

Details Inhibition of influenza virus replication by oligonucleotide pho Inhibition of influenza virus replication by oligonucleotide pho

1990-04-30

1993-03-16

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 27, 536 28, 536 29, A61K 3170, C07H 2100

Patent

active

051944286

ABSTRACT:
A method of inhibiting influenza virus replication through the activity of natural (unmodified) or modified oligonucleotides (oligodeoxynucleotides or oligoribonucleotides) which hybridize to a selected region of the influenza virus RNA and interfere with its ability to serve as a template for synthesis of encoded products. Oligonucleotides (unmodified or modified) which have antiviral activity against influenza virus as a result of their ability to hydridze to a selected region of influenza virus RNA and inhibit its ability to serve as a template for synthesis of encoded products, as well as compositions which include the oligonucleotides.

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