Inhibition of immune clearance using progesterone analogues

Details Inhibition of immune clearance using progesterone analogues Inhibition of immune clearance using progesterone analogues

1987-08-27

1990-02-20

Sneed, H. M. S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514178, 514885, A61K 3156

Patent

active

049026810

ABSTRACT:
Clearance of antibody-coated cells from the circulation of mammals is inhibited by administering an effective amount of 17-hydroxyprogesterone or 16-methylprogesterone. The compounds are useful in treating autoimmune disease.

REFERENCES:
patent: 3463852 (1968-08-01), Reiman et al.
patent: 4701450 (1987-10-01), Kelder et al.
Bach, J. F.; John Wiley & Sons (N.Y.); "Immunology", p. 812 (1982).
Roubinian et al.; Androgenic Hormones Modulate Autoantibody Responses and Improve Survival in Murine Lupus, J. Clin. Invest., 59:1066--1070 (1977).
Chem. Abs. 88:183384 Further Studies on the Angrogenic, Anti-Androgenic, and Synandrogenic Actions of Progestins, Bullock et al., (1978).
Chem. Abs. 81:33775 Inhibition of Lordosis Behavior in Overiectiomized Guinea Pigs by Mesencephalic . . . Morin et al., (1974).
Siiter et al.; Sex Steroids and the Immune System, J. Steroid Biochem., vol. 12, 425-432 (1980).
Duncan et al.; An In Vivo Study of the Action of Antiglucocorticoids on Thymus Weight Ratio, Antibody Titre and the Adrenal-Pituitary-Hypothalamus Axis, (1979), J. Steroid Biochem., vol. 10, 245-259.
Roubinian et al.; Effect of Castration and Sex Hormone Treatment on Survival, Anti-Nucleic Acid Antibodies, and Glomerulonephritis in NZB/NZW F.sub.1 Mice; J. Exp. Med. 147, 1568-1583 (1978).
Nettle et al., "The Effect of Endogenous and Synthetic Steroids on the Clearance of IgG and/or C3 Coated Cells", Blood 64: Suppl. 1:88 A (Abstract) (1984).
Ahn et al., "Danazol for the Treatment of Idiopathic Thrombocytopenic Purpura", N. Eng. J. Med. 308: 1396-1399 (1983).
Schreiber et al., "Effect of Danazol in Immune Thrombocytopenic Purpura", N. Engl. J. Med. 316: 503-508 (Feb. 1987).
Jungers et al., "Hormonal Modulation in Systemic Lupus Erythematosis", Arthritis Rheum. 26: 1243-2150 (1985).
Friedman et al., "Effect of Estradiol and Steroid Analogues on the Clearance of Immunoglobulin G-Coated Erythrocytes", J. Clin. Invest. 75: 162-167 (1985).

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