Inhibition of IL-2 production by Tripterygium wilfordii Hook F e

Details Inhibition of IL-2 production by Tripterygium wilfordii Hook F e Inhibition of IL-2 production by Tripterygium wilfordii Hook F e

1993-10-14

1996-03-19

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

436 63, 935 34, 935 77, C12Q 168, G01N 3350

Patent

active

055003400

ABSTRACT:
The present invention involves the use of Tripterygium Wilfordii Hook F extracts in the treatment of rheumatoid arthritis. An alcohol extract of this plant (T2) inhibited antigen- and mitogen-stimulated proliferation of T cells and B cells, cell cycle progression, interleukin-2 (IL-2) production by T cells, immunoglobulin production by B cells and interleukin-2 mRNA production. T2 did not affect IL-2 receptor expression by T cells, IL-1 production by monocytes, the capacity of monocytes to present antigen, or signaling pathways. Inhibition could not be accounted for by nonspecific toxicity. These results support the conclusion that T2 exerts a powerful suppressive effect on human immune responses. Suppressing autoimmune disease is a most preferred embodiment of this invention.

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