Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-06-07
1999-03-09
McKane, Joseph
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514454, 514716, 514717, 514718, 514721, 514728, 514731, 514732, 514734, A61K 3138, A61K 3135
Patent
active
058801464
ABSTRACT:
Disclosed are chemical agents for modulating certain cellular immune reactions that can lead to autoimmune disorders. By specific modulation, harmful immune reactions can be lessened in severity or even prevented without resorting to potentially dangerous general immune suppression. The described chemical agents inhibit IL-12 induction of the secretion of key immune modulators. The described chemical agents are specific inhibitors of IL-12 induced Th1 immune response.
REFERENCES:
patent: 5185377 (1993-02-01), Schewe et al.
Jontell et al., "Effects of Unpolymerized Resin Components on the Function of Accessory Cells Derived from the Rat Incisor Pulp," J. of Dental Research, 74:1162-1167 (1995).
Correale et al. (1995), "Patterns of Cytokine Secretion by Autoreactive Proteolipid Protein-Specific T Cell Clones During the Course of Multiple Sclerosis," 154 The Journal of Immunology, 2959-2968.
Germann et al. (1995), "Administration of Interleukin 12 in Combination with Type II Collagen Induces Severe Arthritis in DBA/1 Mice," 92 Proc. Natl. Acad. Sci. USA; 4823-4827.
Article Abstract (1993), "Interferon Beta-1b is Effective in Relapsing-Remitting Multiple Scherosis. I. Clinical Results of a Multicenter, Randomized, Double-Blind, Placebo-controlled Trial," 43 Neurology; 655-661.
Mosmann et al. (1989), "TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties," 7 Ann. Rev. Immunol.; 145-173.
Gillies Stephen D.
Wesolowski John
Fuji ImmunoPharmaceuticals Corporation
McKane Joseph
LandOfFree
Inhibition of IL-12-induced IFN-.gamma. synthesis by specific bi does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Inhibition of IL-12-induced IFN-.gamma. synthesis by specific bi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibition of IL-12-induced IFN-.gamma. synthesis by specific bi will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1321487