Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2003-03-12
2010-02-16
McGarry, Sean (Department: 1635)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C536S023100, C536S024300, C536S024330, C536S024500
Reexamination Certificate
active
07662793
ABSTRACT:
A nucleic acid is provided comprising an expression cassette which includes transcription control sequences of a member of a class of Pol III-transcribed genes in which no transcribed portion of the Pol III gene is required for transcription of the gene. In the expression cassette, the transcribed 5′ hairpin structure of the Pol III gene is deleted. The transcription control sequences are operably linked to a sequence of an EGFR gene in an antisense orientation suitable for decreasing expression of EGFR in the cell when transcribed. Lastly, a method for decreasing expression of EGFR in cells is provided that includes the step of contacting target cells either parenterally or directly into the tumor or tissue adjacent to the tumor cells with the nucleic acid of the present invention.
REFERENCES:
patent: 5610288 (1997-03-01), Rubenstein
He et al. Inhibition of Human Squamous Cell Carcinoma Growth In vivo by Epidermal Growth Factor Receptor Antisense RNA Transcribed From the U6 Promoter. Journal of Natl. Cancer Inst., 1998 vol. 90:1080-1087.
He et al. Growth Inhibiton of Human Papillomavirus 16 DNA-positive mouse tumor by antisense RNA transcribed from U6 Promoter. Cancer Research, 1997 vol. 57:3993-3999.
Good et al. (Gene Therapeutics, 1997 vol. 4:45-54).
Grandis Jennifer R.
He Yukai
Huang Leaf
Gibbs Terra Cotta
Johnson, Esq. Barbara E.
McGarry Sean
University of Pittsburgh of the Commonwealth System of Higher Ed
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