Inhibition of Hepatitis B virus by cyclohexenone compounds...

Details Inhibition of Hepatitis B virus by cyclohexenone compounds... Inhibition of Hepatitis B virus by cyclohexenone compounds...

2007-08-21

2008-08-12

Witherspoon, Sikari A (Department: 1621)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ketone doai

C568S377000

Reexamination Certificate

active

07411003

ABSTRACT:
The present invention relates to a compound ofAntrodia camphorataused to inhibit HBV, in particular to an extract, 4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone which is isolated fromAntrodia camphorata,and its use in inhibiting HBV effectively. The cyclohexenone compound according to the present invention showed cytotoxicity on HBV-secreting human hepatoma cell line HepG2 2.2.15, decreased synthesis of HBV particles, further inhibited synthesis of HbsAg and HbeAg effectively to achieve the goal of HBV inhibition.

REFERENCES:
Shu-Wei Yang et al., “Steroids and Triterpenoids ofAntrodia cinnamomea-AFungus Parasitic onCinnamomum micranthum,” Phytochemistry, vol. 41, No. 5, pp. 1389-1392, 1996.
I-Hwa Chering et al., “Triterpenoids fromAntrodia cinnamomea,” Phytochemistry, vol. 41, No. 1, pp. 263-267, 1996.
Hung-Chen Chiang et al., “A Sesquiterpene Lactone, Phenyl and Biphenyl Compounds fromAntrodia cinnamomea,” Phytochemistry, vol. 39, No. 3, pp. 613-616, 1995.
I-Hwa Chering et al., “Three New Triterpenoids FromAntrodia cinnamomea,” Journal of Natural Products, vol. 58, No. 3, pp. 365-371, Mar. 1995.
Chung-Hsiung et al.,“New Steroid Acids FromAntrodia cinnamomea, A Fungal Parasite ofCinnamomum micranthum,” Journal of Natural Products, vol. 58, No. 11, pp. 1655-1661, Nov. 1995.
Mary Ann Sells et al., “Production of Hepatitis B Virus Particles in HEP G2 Cells Transfected With Cloned Hepatitis B Virus DNA,” Proc. Natl. acad. Sci. USA, vol. 84, 1005-1009, Feb. 1987.

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