Inhibition of Gram positive bacteria

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C424S070100

Reexamination Certificate

active

07026353

ABSTRACT:
A method of inhibiting the growth of a Gram positive bacterium, the method comprising treating the bacterium with an effective amount of one or more furanones having the Formula as set out in the Figure, wherein the effective amount of the one or more furanones does not substantially adversely effect the survival of an animal cell when exposed to the one or more furanones

REFERENCES:
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patent: WO 96 29392 (1996-09-01), None
patent: WO 99 54323 (1999-10-01), None
Reichelt, J L et al. (1984) “Antimicrobial Activity from Marine Algae: Results of a Large-Scale Screening Programme.” Hydrobiologia, Junk, The Hague, NL, 116/117:158-168.
Manny, A J et al. (1997) “Reinvestigation of the Sulfuric Acid-Catalysed Cyclisation of Brominated 2-Alkyllevulinic Acids to 3-Alkyl-5-Methylene-2(5H)-Furanones.” Tetrahedron, Elsevier Scientific Publishing, Amsterdam, NL, 53(46):15813-15826.
Chemical Abstracts 99: 200391 “Antimicrobial Constituents (of Marine Algae)”, Ochi, Masamitsu, Suisangaku, Shiriizu (1983), 45 (Kaiso no. Seikagaku to Riyo), 101-19, Abstract only.
De Nys et al., (1995) “Broad Spectrum Effects of Secondary Matabolites From the Red AlgaDelisea pulchraIn Antifouling Assays”, Biofouling, 8:259-271.
Kotsuki, Hiyoshizo et al., (1983) “Efficient Synthesis of Acetoxyfimbrolides and Beckerelides Analogs”, Chemistry Letters, pp. 1007-1008 (The Chemical Society of Japan).

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