Inhibition of glutathione transferase by haloenol lactones

Plant protecting and regulating compositions – Plant growth regulating compositions – Plural active ingredients

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504297, 514 18, A01N 4302, A01N 4308

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06103665&

ABSTRACT:
This invention relates to novel haloenol lactone compounds. These compounds have the following general structure: ##STR1## in which Ar is an aryl group and Y is a haloenol lactone moiety. The compounds of the invention are useful for the specific measurement of particular isoenzymes of glutathione S-transferase. Measurement of glutathione S-transferase isoenzymes has importance in diagnostic medicine. The compounds of the invention are also useful for treatment of drug resistance in cancer and for preventing herbicide resistance in plants.

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