Inhibition of glial cell proliferation with N-CAM homophilic pep

Details Inhibition of glial cell proliferation with N-CAM homophilic pep Inhibition of glial cell proliferation with N-CAM homophilic pep

1995-05-08

1999-11-16

Duffy, Patricia A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 15, 530300, 530327, 530328, 530350, A61K 3800, C07K 500

Patent

active

059858222

ABSTRACT:
Methods and compositions are disclosed that are useful for the inhibition of glial cell proliferation by means of binding inhibiting agents to neural cell adhesion (N-CAM) molecules present on the cell surface. Such inhibiting agents can be peptides derived from the homophilic binding region of N-CAM, monoclonal antibodies, polyclonal antibodies, Fab' fragments, and the like. Exemplary N-CAM homophilic peptides are 7 to 90 amino acid residues having a positively charged amino acid residue separated from a negatively charged amino acid residue by five intervening amino acid residues.

REFERENCES:
Barrett, C. P. et al. (1984) Exp. Neurol. 84, 374-385.
Bickel, U. et al. (1993) Proc. Natl. Acad. Sci. USA 90 2618-2622.
Crossin, K. L. (1991) Proc. Natl. Acad. Sci. USA 88, 11403-11407.
Cunningham, B. A. et al. (1987) Science 236, 799-806.
Daniloff, J. K. et al. (1986) J. Cell Biol. 103, 929-945.
Doherty, P. & Walsh, F. S. (1994) Current Opinion in Neurobiology 4, 49-55.
Edelman, G. M. (1986) Ann. Rev. Cell Biol. 2, 81-116.
Flanders, K. C. et al. (1991) Development 113, 183-191.
Gasser, U. E. & Hatten, M. E. (1990) J. Neurosci. 10, 1276-1285.
Gerdes, W. et al. (1992) NeuroReport 3, 43-46.
Hatten, M. E. (1987) J. Cell. Biol. 104, 1353-1360.
Hemperly, et al. (1986) Proc. Natl. Acad. Sci. USA 83, 3037-3041.
Hoffman, S. et al. (1982) J. Biol. Chem. 257, 7720-7729.
Hunter, K. E., et al. (1993) Glia 7, 203-211.
Krushel, L.A., et al. (1995) Proc. Natl. Acad. Sci. USA 92, 4323-4327.
Ludwin, S. K. (1984) Nature 308, 274-275.
Murray, et al., (1986) J. Cell Biology 102: 189-193.
Rao et al., (1992) J. Cell Biology 118: 937-949.
Rao et al., (1993) J. Biological Chemistry 268: 20630-20638.
Sandig, M., et al (1994) J. Biol. Chem. 269, 14841-14848.
Searle, P.F. et al. (1985) Molec. & Cell. Biol.5, 1480-1489.
Small, S. J., Shull, G. E., Santoni, M. J. & Akeson, R. (1987) J. Cell. Biol. 105, 2335-2345.
Brackenbury, R. et al., (1977) J. Biol. Chem. 252, 6835-6840.
Frei et al, J. Cell. Biol.(USA) 118(1): 177-194, 1992.
Barinago et al, Science 264:772-774, 1994.
Rudinger, "Peptide Hormones" Published by University Park Press, Jun. 1976, pp. 1-6.
Bargess et al, Journal of Cell Biology 111:2129-2138, 1990.
Lazar et al, Molecular and Celluar Biology, 8(3):1247-1252, 1988.

Affiliated with

Also associated with

Rating

Inhibition of glial cell proliferation with N-CAM homophilic pep does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibition of glial cell proliferation with N-CAM homophilic pep, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibition of glial cell proliferation with N-CAM homophilic pep will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1324709