Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1982-04-28
1983-05-17
Schwartz, Richard A.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
424267, 542400, 542429, 546213, 546221, 546227, 546239, 546284, 546322, A61K 31455, A61K 31445, C07D21178, C07D21160
Patent
active
043839991
ABSTRACT:
N-Substituted azaheterocyclic carboxylic acids and their esters, useful as inhibitors of GABA uptake, are prepared by reacting an appropriate N-alkylating derivative with an ester of an N-unsubstituted azaheterocyclic carboxylic acid followed by hydrolysis of the ester.
REFERENCES:
patent: 3575990 (1971-04-01), Hermans et al.
patent: 4024264 (1977-05-01), Bjork et al.
Sam, J., et al., J. Am. Chem. Soc., 81:710-13 (1959).
Thayer, J., et al., J. Am. Chem. Soc., 49:2862-9 (1928).
C. A. 59:13936f [Kempter, G., et al., Z. Chem., 3(8), 305-7 (1963)].
Lee, D., et al., J. Org. Chem., 39(7):893-902 (1974).
Derwent Abstract 34609F (1968).
Bondinell William E.
Lafferty John J.
Zirkle Charles L.
Foggio Richard D.
Lourie Alan D.
Schwartz Richard A.
SmithKline Beckman Corporation
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