Surgery: light – thermal – and electrical application – Light – thermal – and electrical application – Light application
Patent
1996-10-31
1999-06-22
Tsang, Cecilia J.
Surgery: light, thermal, and electrical application
Light, thermal, and electrical application
Light application
607 92, A61B 1700
Patent
active
059138840
ABSTRACT:
Disclosed is a method for modulating wound healing in a mammal. The method includes the steps of: (a) administering a photosensitizer to a mammal that has an unhealed or partially-healed wound; (b) waiting for the photosensitizer to reach an effective tissue concentration at the wound site; (c) photoactivating the photosensitizer by delivering specifically to the wound site light of a effective wavelength and intensity, for an effective length of time. The modulation of wound healing can include hastening healing by administering a low dose of photodynamic therapy. Alternatively, the modulation can include inhibiting fibrosis by administering a high dose of photodynamic therapy. The photosensitizer can be targeted, for example, to macrophages or myofibroblasts. Targeting can be by conjugation to a targeting moiety such as a protein, peptide or microparticle.
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Hamblin Michael R.
Hasan Tayyaba
Trauner Kenneth
Delaney Patrick R.
The General Hospital Corporation
Tsang Cecilia J.
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