Inhibition of FGFR3 and treatment of multiple myeloma

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Reexamination Certificate

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07825132

ABSTRACT:
Methods of inhibiting fibroblast growth factor receptor 3 and treating various conditions mediated by fibroblast growth factor receptor 3 are provided that include administering to a subject a compound of Structure I, a pharmaceutically acceptable salt thereof, a tautomer thereof, or a pharmaceutically acceptable salt of the tautomer. Compounds having the Structure I have the following structure where and have the variables described herein. Such compounds may be used to prepare medicaments for use in inhibiting fibroblast growth factor receptor 3 and for use in treating conditions mediated by fibroblast growth factor receptor 3 such as multiple myeloma.

REFERENCES:
patent: 3663606 (1972-05-01), Yoshikazu
patent: 4659657 (1987-04-01), Harnisch et al.
patent: 4882342 (1989-11-01), Von der Saal et al.
patent: 5073492 (1991-12-01), Chen et al.
patent: 5151360 (1992-09-01), Handa et al.
patent: 5330992 (1994-07-01), Eissenstat et al.
patent: 5414088 (1995-05-01), Von Der Saal et al.
patent: 5480883 (1996-01-01), Spada et al.
patent: 5585380 (1996-12-01), Bianco et al.
patent: 5646153 (1997-07-01), Spada et al.
patent: 5710158 (1998-01-01), Myers et al.
patent: 5763441 (1998-06-01), App et al.
patent: 5792771 (1998-08-01), App et al.
patent: 5801212 (1998-09-01), Okamoto et al.
patent: 5855866 (1999-01-01), Thorpe et al.
patent: RE36256 (1999-07-01), Spada et al.
patent: 5942385 (1999-08-01), Hirth
patent: 5981569 (1999-11-01), App et al.
patent: 6057320 (2000-05-01), Spada et al.
patent: 6111110 (2000-08-01), Brennan et al.
patent: 6137010 (2000-10-01), Joo et al.
patent: 6174912 (2001-01-01), Beck et al.
patent: 6258951 (2001-07-01), Lohmann et al.
patent: 6268391 (2001-07-01), Dickerson et al.
patent: 6303600 (2001-10-01), Cox et al.
patent: 6306874 (2001-10-01), Fraley et al.
patent: 6313138 (2001-11-01), Fraley et al.
patent: RE37650 (2002-04-01), Myers et al.
patent: 6420382 (2002-07-01), Fraley et al.
patent: 6479512 (2002-11-01), Fraley et al.
patent: 6593344 (2003-07-01), Biedermann et al.
patent: 6605617 (2003-08-01), Renhowe et al.
patent: 6756383 (2004-06-01), Renhowe et al.
patent: 6759417 (2004-07-01), Renhowe et al.
patent: 6762194 (2004-07-01), Renhowe et al.
patent: 6774237 (2004-08-01), Renhowe et al.
patent: 6774327 (2004-08-01), Wong
patent: 6800760 (2004-10-01), Renhowe et al.
patent: 7064215 (2006-06-01), Renhowe et al.
patent: 7179912 (2007-02-01), Halbrook et al.
patent: 7470709 (2008-12-01), Barsanti et al.
patent: 7598268 (2009-10-01), Renhowe et al.
patent: 2002/0103230 (2002-08-01), Renhowe et al.
patent: 2002/0107392 (2002-08-01), Renhowe et al.
patent: 2002/0165218 (2002-11-01), Halbrook et al.
patent: 2003/0028018 (2003-02-01), Renhowe et al.
patent: 2003/0087854 (2003-05-01), Monia et al.
patent: 2003/0158224 (2003-08-01), Renhowe et al.
patent: 2003/0159702 (2003-08-01), Lindell et al.
patent: 2003/0207883 (2003-11-01), Renhowe et al.
patent: 2004/0002518 (2004-01-01), Renhowe et al.
patent: 2004/0006101 (2004-01-01), Renhowe et al.
patent: 2004/0092535 (2004-05-01), Barsanti et al.
patent: 2004/0097545 (2004-05-01), Renhowe et al.
patent: 2004/0220196 (2004-11-01), Hannah et al.
patent: 2005/0054672 (2005-03-01), Renhowe et al.
patent: 2005/0137399 (2005-06-01), Cai et al.
patent: 2005/0203101 (2005-09-01), Barsanti et al.
patent: 2005/0209247 (2005-09-01), Cai et al.
patent: 2005/0256157 (2005-11-01), Gesner et al.
patent: 2005/0261307 (2005-11-01), Cai et al.
patent: 2006/0261307 (2006-11-01), Black et al.
patent: 2003290699 (2004-06-01), None
patent: 2421120 (2002-03-01), None
patent: 23463 (2003-11-01), None
patent: 2363459 (1975-06-01), None
patent: 3634066 (1988-04-01), None
patent: 19841985 (2000-03-01), None
patent: 0290153 (1988-11-01), None
patent: 0 509 717 (1992-04-01), None
patent: 0 508 800 (1992-10-01), None
patent: 0 747 771 (1996-12-01), None
patent: 0 797 376 (1997-09-01), None
patent: 0 290 153 (1998-11-01), None
patent: 1 086 705 (2001-03-01), None
patent: P104752 (2002-07-01), None
patent: 59-130284 (1984-07-01), None
patent: 63-230687 (1988-09-01), None
patent: 02-229165 (1990-09-01), None
patent: 6-9952 (1994-01-01), None
patent: 7-43896 (1995-02-01), None
patent: 8-29973 (1996-02-01), None
patent: 63-258903 (1998-10-01), None
patent: WO 91/04974 (1991-04-01), None
patent: 92/18483 (1992-10-01), None
patent: 92/20642 (1992-11-01), None
patent: WO-94/11337 (1994-05-01), None
patent: 95/15758 (1995-06-01), None
patent: 95/18801 (1995-07-01), None
patent: WO-95/18622 (1995-07-01), None
patent: 97/03069 (1997-01-01), None
patent: WO-97/21436 (1997-06-01), None
patent: 97/34876 (1997-09-01), None
patent: 97/48694 (1997-12-01), None
patent: 98/13350 (1998-04-01), None
patent: WO 98/55124 (1998-12-01), None
patent: 99/10349 (1999-03-01), None
patent: WO-99/16755 (1999-04-01), None
patent: WO-99/48868 (1999-09-01), None
patent: 99/50263 (1999-10-01), None
patent: 99/65897 (1999-12-01), None
patent: WO 00/00481 (2000-01-01), None
patent: WO-00/03990 (2000-01-01), None
patent: WO 00/03990 (2000-01-01), None
patent: WO-00/11709 (2000-03-01), None
patent: WO 00/20400 (2000-04-01), None
patent: 00/27379 (2000-05-01), None
patent: WO-00/31049 (2000-06-01), None
patent: WO-00/35492 (2000-06-01), None
patent: WO 00/58315 (2000-10-01), None
patent: WO 00/71129 (2000-11-01), None
patent: WO 00/74683 (2000-12-01), None
patent: WO 0074683 (2000-12-01), None
patent: 01/02369 (2001-01-01), None
patent: WO 01/12169 (2001-02-01), None
patent: 01/28993 (2001-04-01), None
patent: 01/29025 (2001-04-01), None
patent: WO 01/28993 (2001-04-01), None
patent: 01/52904 (2001-07-01), None
patent: WO 01/52875 (2001-07-01), None
patent: WO 01/53268 (2001-07-01), None
patent: 01/55114 (2001-08-01), None
patent: 01/62251 (2001-08-01), None
patent: 01/62252 (2001-08-01), None
patent: WO 01/74296 (2001-10-01), None
patent: 02/18383 (2002-03-01), None
patent: 02/22598 (2002-03-01), None
patent: WO 02/18383 (2002-03-01), None
patent: WO 02/22598 (2002-03-01), None
patent: 02/32861 (2002-04-01), None
patent: WO 02/26716 (2002-04-01), None
patent: WO 02/058697 (2002-08-01), None
patent: 03/004488 (2003-01-01), None
patent: WO 03/033472 (2003-04-01), None
patent: WO 03/087095 (2003-10-01), None
patent: WO 2004/018419 (2004-03-01), None
patent: 2004/030620 (2004-04-01), None
patent: 2004/031401 (2004-04-01), None
patent: WO 2004/030620 (2004-04-01), None
patent: WO 2004/043389 (2004-05-01), None
patent: 2004/063151 (2004-07-01), None
patent: WO 2004/063170 (2004-07-01), None
patent: WO-2004/073631 (2004-09-01), None
patent: WO 2004/087153 (2004-10-01), None
patent: WO-2004/103274 (2004-12-01), None
patent: WO-2005/009967 (2005-02-01), None
patent: WO-2005/037306 (2005-04-01), None
patent: WO 2005/046589 (2005-05-01), None
patent: WO 2005/046590 (2005-05-01), None
patent: WO-2005/047244 (2005-05-01), None
patent: WO 2005/053692 (2005-06-01), None
patent: WO 2005/082340 (2005-09-01), None
patent: WO 2006/081445 (2006-08-01), None
patent: WO-2006/127926 (2006-11-01), None
Cecil, Textbook of Medicine, 21stEdition (2000), Goldman & Bennett (Editors), W.B. Saunders Company (Publisher), Chapter 198, pp. 1060-1074).
U.S. Appl. No. 10/982,543, filed Nov. 5, 2004, Cai et al.
U.S. Appl. No. 10/982,757, filed Nov. 5, 2004, Cai et al.
Aprelikova, O., et al., “FLT4, a novel Class III Receptor Tyrosine Kinase in chromosome 5q33-qter1,”Cancer Res., vol. 52, pp. 746-748, Feb. 1, 1992, published by The American Association for Cancer Research, Stanford University Libraries' high Wire Press, California, United States of America.
Beals, C. R. et al., “Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3,”Science, vol. 275, pp. 1930-1933, Mar. 28, 1997.
Brownlees, J. et al., “Tau phosphorylation in transgenic mice expressing glycogen synthase kinase-3β transgenes,”NeuroReport, vol. 8, No. 15, pp. 3251-3255, Oct. 20, 1997; published by Rapid Science Publishers.
Carmeliet, P. et al. “Angiogenesis in Cancer and other Diseases,” Nature, 407, pp. 249-257 (2000).
Chan, T. A. et al., “14-3-3σ is required to

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