Inhibition of farnesyl transferase

Details Inhibition of farnesyl transferase Inhibition of farnesyl transferase

1995-01-12

1998-01-06

Tsang, Cecilia J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

514 19, 564308, 564337, A61K 3805, C07C32100, C07C21100

Patent

active

057056862

ABSTRACT:
A compound of the formula

REFERENCES:
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Vogt, J Biol Chem 270, 660, 1995.
Sako, Chem Pharm Bull 40, 49, 1992.
Harrington, Biorg Med Chem Lett vol. 4, 2775, 1994.
Hancock et al, "A polybasic Domain or Palmitoylation is Required in Addition to the CAAX Motif to Localize p21.sup.ras to the Plasma Membrane", Cell, vol. 63, Oct. 5, 1990, pp. 133-139.
Reiss et al, "Inhibition of Purified p21.sup.ras Farnesyl:Protein Transferase by Cys-AAX Tetrapeptides", Cell, vol. 62, Jul. 13, 1990, pp. 81-88.
Willumsen et al, "The p21 ras C-terminus is required for transformation and membrane association," Nature, vol. 310, Aug. 16, 1984, pp. 583-586.

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