Inhibition of expression of beta-lactamase using esters of fatty

Details Inhibition of expression of beta-lactamase using esters of fatty Inhibition of expression of beta-lactamase using esters of fatty

1995-06-06

1997-05-27

Fay, Zohreh

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514546, 514547, 514558, 514560, A61K 31545, A61K 3122, A61K 31225, A61K 3120

Patent

active

056332459

ABSTRACT:
A class of chemical compounds comprising fatty acid ester derivatives used to inhibit beta-lactamase production by infectious bacteria. These inhibitors have been found to retard the resistance of certain strains of bacteria to beta-lactam antibiotics, such as penicillin, by interfering with the transcription of the beta-lactamase gene and precluding expression of beta-lactamase. In accordance therewith, these inhibitors permit effective treatment of infections of otherwise resistive bacteria with antibiotics.

REFERENCES:
Biosis Abstract of Journal of Antibiotics (1981).
Biosis Abstract of Food Prot. (1992).

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