Inhibition of endogenous gastrin expression for treatment of col

Chemistry: molecular biology and microbiology – Vector – per se

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435 601, 4351723, 435325, 514 44, 514 2, 424 9321, 536 231, 536 223, 536 243, C12N 500

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057862133

ABSTRACT:
The present invention discloses is for the treatment of colon cancer. The expression of gastrin by colon cancers is inhibited by the use of antisense gastrin expression. Methods are disclosed for the preparation of expression constructs and the use of such constructs to inhibit colon cancer growth.

REFERENCES:
patent: 5190931 (1993-03-01), Inouye
patent: 5585479 (1996-12-01), Hoke et al.
Ito et al., "Structural analysis of the gene encoding human gastrin: The large intron contains an Alu sequence," Proc. Natl. Acad. Sci. USA, 81:4662-66, 1984.
Baldwin et al., "PCR Cloning and Sequence of Gastrin mRNA from Carcinoma Cell Lines," Biochemical and Biophysical Research Communications, 170(2):691-697, Jul. 1990.
Chicone et al., "The Presence of a 33--40 Kda Gastrin Binding Protein on Human and Mouse Colon Cancer," Biochemical and Biophysical Research Communications, 164(1):512-519, Oct. 1989.
Finley et al., "Expression of the Gastrin Gene in the Normal Human Colon and Colorectal Adenocarcinoma," Cancer Research, 53:2919-2926, Jun. 1993.
Hoosein et al., "Antiproliferative Effects of Gastrin Receptor Antagonists and Antibodies to Gastrin on Human Colon Carcinoma Cell Lines," Cancer Research, 48:7179-7183, Dec. 1989.
Imdahl et al., "Expression of Gastrin, Gastrin/CCK-B-and Gastrin/CCK-C Receptors in Human Colorectal Carcinomas," Gastroenterology, 108(4):A484.
Kato et al, "Molecular Cloning of Human Gastrin Precursor cDNA," Gene, 26:53-57, 1983.
Lebovitz et al., "The Role of Gastrin in Colorectal Cancer Cell Lines," Proceedings of the American Association for Cancer Research, 35:42, Abstract No. No. 248, Mar. 1994.
Rehfeld and Hilsted, "Gastrin and Cancer," Advances in Clinical Chemistry, 29:239-262, 1992.
Singh et al., "Novel Gastrin Receptors Mediate Mitogenic Effects of Gastrin and Processing Intermediates of Gastrin on Swiss 3T3 Fibroblasts," The Journal of Biological Chemistry, 270(15):8429-8438, Apr. 1995.
Singh et al., "Anti-Tumorigenic Effects of a Recombinant Retrovirus Over-Expressing Antisense Gastrin cDNA on a Human Colon Cancer Cell Line," Annual Meeting of American Gastroenterological Association and American Association for the Study of Liver Diseases, May 19-22, 1996.
Singh et al., "Incomplete Processing of Progastrin Expressed by Human Colon Cancer Cells: Role of Noncarboxyamidated Gastrins," The American Physiological Society, G459-G468, 1994.
Upp et al., "Clinical Significance of Gastrin Receptors in Human Colon Cancers," Cancer Research, 49:488-492, Jan. 1989.
Xu et al., "Gastrin Gene Expression in Human Colon Cancer Cells Measured by a Simple Competitive PCR Method," Life Sciences, 54(10):671-678, 1994.
Ledley, "Somatic Gene Therapy in Gastroenterology: Approaches and Applications",Journal of Pediatric Gastroenterology and Nutrition, 14:328-337, 1992.
International Search Report for PCT/US97/06528, mailed Jun. 24, 1997.
Gilboa, Seminars In Oncology, vol. 23, 1 : 101-107, 1996.
Mashangelo et al., Seminars In Oncology, vol. 23, 1 : 4-21, 1996.
Jeun, Scientific American, Jul. 1994, pp. 58-65.
Herrman. J. Mol. Med. Today. 1995, 73:157-163.
Ronald Crystal. Science. 1995, 270:404-409.
Coghlan. New Scientist. 1995, vol. 148, pp. 14 and 15, 1995.
Wagner et al. Nature. 1994, vol. 372:333-335.
Gura. Science. 1995, 270:575-577.
Plenat. J. Mol. Med. Today. 1996, vol. 2, No. 6:250-257.
Bold et al. Surgery. 1994, 116/2:189-95.
Kato et al. Gene. 1983, 2:53-57.

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