Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-02-07
1987-10-20
Brown, J. R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514562, 514867, A61K 3141, A61K 31195
Patent
active
047014580
ABSTRACT:
Substantially nontoxic materials such as cysteamine constituting a source of sulfhydryl groups are useful in inhibiting diarrhea induced by Escherichia coli heat-stable enterotoxin. Such materials block ST-induced secretion prior to the formation of cyclic GMP without interference with normal basal activity or metabolism and may inactivate ST itself by breaking disulfide bridges. Combinations of a substantially nontoxic material constituting a source of sulfhydryl groups and an alpha-2 adrenergic receptor, such as naphazoline, or berberine are also useful in inhibiting such diarrhea.
REFERENCES:
patent: 4587265 (1986-05-01), Greenberg
Doherty et al J. Pharm. Exp Ther. 225:269-274, 1983.
Jacks et al B134, Abst. of Annual Meeting of ASM 1983.
Spraggs, et al., J Pharm Pharmacsl 35:321-322, 1983.
Berthelsen, et al., Life Sci. 21: 593-606, 1977.
Brown J. R.
Rollins Jr. John W.
St. Louis University
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