Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism
Patent
1998-01-09
1999-03-16
Leary, Louise N.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving viable micro-organism
435 29, 435 34, 435 4, 435 41, 435 39, 4352402, 43524023, 436 63, 514462, 514629, 540478, 549345, C12Q 124, C12Q 102, C12Q 110, C12N 500
Patent
active
058828818
ABSTRACT:
The invention provides a method of producing a culture of polycystic kidney cells which form cysts in vitro. A cell culture of polycystic kidney cells is also provided. A method for screening an agent in vitro to determine the effectiveness of the agent in treating polycystic kidney disease is disclosed. Further, a method of treating a mammal having polycystic kidney disease by administering a pharmaceutical composition is provided.
REFERENCES:
patent: 4697600 (1987-10-01), Cardenas et al.
patent: 4814470 (1989-03-01), Colin et al.
patent: 4853221 (1989-08-01), Elslager et al.
patent: 4870162 (1989-09-01), Trovet et al.
patent: 4882314 (1989-11-01), Takeuchi et al.
patent: 4929542 (1990-05-01), Risley
patent: 4962187 (1990-10-01), Pant
patent: 4983636 (1991-01-01), Takeuchi et al.
patent: 5086476 (1992-02-01), Bacus
patent: 5124338 (1992-06-01), King
patent: 5352805 (1994-10-01), Kingston et al.
patent: 5455161 (1995-10-01), Assaraf et al.
Wilson, P.; Cell Biology of Human Autosomal Dominant Polycystic Kidney Disease 1991. 11(6); pp. 607-616.
Wilson, P. and A. Sherwood, Tubulocystic Epithelium, Kidney Int., 1991. 39:pp. 450-463.
Wilson, P.D. Aberrant epithelial cell growth in autosomal dominant polycystic kidney disease; Am J. Kidney Dis., 1991. 17(6): pp. 634-637.
Wilson, P.D., et al., Reversed polarity of Na(+) -K(+) -ATPase: mislocation to apical plasma membrances in polycystic kidney disease epithelia; Am J. Physiol, 1991. 260: pp. F420-F430.
Gattone, V. and J. Grnatham, Understanding Human Cystic Desease Through Experimental Models. Seminars in Nephrology, 1991. 11( ): pp. 617-631.
Gabow, P. and W. Bennet, Renal Manifestations: Complication Management and Long-Term Outcome of Autosomal Dominant Polysystic Kidney Disease 1991. 11(6): pp. 643-652.
Grantham, J.J., Polycystic kidney disease: a predominance of giant nephrons. Am J. Physiol, 1983. 244(1): pp. F3-F10.
Grantham, J.J., (1988)m Polycystic kidney desease--an old problem in a new context {editorial}. N Engl J. Med, 319(14), 944-6.
Grantham, J.J., J.L. Geiser and A.P. Evan, Cyst formation and growth in autosomal dominant polycystic kidney disease. Kidney Int., 1987. 31(5): pp. 1145-1152.
Mangoo, K.R. et al., Ranal epithelial fluid secretion and cyst growth; the role of cyclic AMP. Faseb J, 1989, 3(14): pp. 2629-2932.
Avner, E.D., et al., Congenital murine polycystic kidney disease. I. The ontogeny of tubular cyst formation. Pediatr Nephrol, 1987. 1(4): pp. 587-596.
Avner, E.D., et al. "Sodium-potassium ATPase activity mediates cyst formation in metanephric organ culture"; Kidney Int., 1985. 28(3): pp. 447-455.
Avner, E.D., et al. "Congenital murine polycystic kidney disease"; II. Pathogenesis of tubular cyst formation. Pediatr Nephrol. 1988. 2(2): pp. 210-218.
Wani, M. and et al., "Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia"; J. Am. Chem. Soc. 1971. 93: pp. 2325-2327.
Schiff, P., J. Fant, and S. Horwitz, Promotion of microtubule assembly in virto by taxol. Nature, 1979, vol. 277, pp. 665-667.
Schiff, P. and S. Horwitz, Taxol Stabilizes microtubules in mouse fibroblast cells. Proc. Nat. Acad. Sci. 1980. 77: pp. 1561-1565.
Neufeld, T.K., et al., J.J. Kidney Int. 41: 1222-1236 (1992). In vitro formation and expansion of cysts derived from human renal cortex epithelial cells.
K.D. Gardner, in The Cystic Kidney, K.D. Gardner, J. Bernstein, Eds. (Kluwer Academic Publishers, Hingham, MA, 1990). pp. 3-17; "Cysts and Cystic Kidneys".
E. Levine, J.J. Grantham, in The Cystic Kidney, K.D. Gardner, J. Bernstein, Eds. (Kluwer Academic Publishers, Hingman, MA, 1990) pp. 171-206, "Radiology of Cystic Kidneys".
W.J. Kimberling, et al., N. Engl. J. Med. 319, 913-917 (1988); "Linkage Heterogeneity of Autosomal Dominant Polycystic Kidney Disease".
L. Bachner, et al., Hum Genet 85 221-217 (1990); "Linkage study of a large family with autosomal dominant polycystic kidney disease with reduced expression".
G. Romeo, et al., Lancet, 2, 8-10 (1988); "A Second Genetic Locus For Autosomal Dominant Polycystic Kidney Disease".
S. Norby, W.W.S. Sorensen, P. Boesen, In Genetics of Kidney Disorders. (1989), vol. 305, pp. 83-88; "Non-Allelic Genetic Heterogeneity of Autosomal Dominant Polycystic Kidney Disease?".
S.T. Reeders, et al., Nature 317, 542-4 (1985); "A highly polymorphic DNA marker linked to adult polycystic kidney disease on chromosome 16".
S.T. Reeders, et al., Lancet 8497, 6-8 (1986); "Prenatal Diagnosis of Autosomal Dominant Polycystic Kidney Disease with a DNA Probe".
P.D. Wilson, R.W. Schrier, R.D. Breckon, P.A. Gabow, Kidney Int. 30, 371-378 (1986); "A new method for studying human polycystic kidney disease epithelia in culture".
A.H. Yang, K.H. Gould, T.D., Oberley, In Vitro Cell Dev Biol 23, 34-46 (1987); "In vitro growth and differentiation of Human Kidney Tubular Cells on a Basement Membrane Substrate".
F.A. Carone, S. Nakamura, B.S. Schumacher, P. Punyarit, K.D. Bauer, Kidney Int. 35, 1351-1357 (1989); "Cyst-derived cells do not exhibit accelerated growth or features of transformed cells in vitro".
J.D. Valentich, R. Tchao, J. Leighton, J. Cell Physio 100, 291-304 (1979); "Hemicyst Formation Stimulated by Cyclic AMP in Dog Kidney Cell Line MDCK".
T.P. Fleming, M.H. Johnson, Annu Rev Cell Bio 4, 459-85 (1988); "From Egg to Epithelium".
F.E. Cuppage, R.A. Huseman, A. Chapman, J.J. Grantham, Kidney Int. 17, 372-81 (1980); "Ultrastructure and Function of Cysts from Human Adult Polycystic Kidneys".
S.K. Katz, A. Hakki, A.S. Miller, F.S.D., Ann. Clin. Lab.Sci. 19, 352-359 (1989); "Ultrastructural Tubular Basement Membrane Lesions in Adult Polycystic Kidney Disease".
I. Ebihara, et al., Lab. Invest, 58, 262-269 (1988); "Altered mRNA Expression of Basement Membrane Components in a Murine Model of Polycystic Kidney Disease".
M. Taub, G.W. Laurie, G.R. Martin, H.K. Kelinman, Kidney Int. 37, 1090-1097 (1990); "Altered basement membrane protein biosynthesis by primary cultures of cpk/cpk mouse kidney".
Y.S. Kanwar, F.A. Carone, Kidney Int 26, 35-43 (1984); "Reversible changes of tubular cell and basement membrane in drug-induced renal cystic disease".
F.A. Carone, Semin Nephrol 8, 89-93 (1988); "Functional Changes in Polycystic Kidney Disease are Tubulo-Interstitial in Origin".
J.J. Grantham, Am J Kidney Dis 15, 110-6 (1990); "Polycystic Kidney Disease: Neoplasia In Disguise".
G.M. Edelman, A Rev. Cell Biol. 2, 81-116 (1986); "Cell Adhesion Molecule in the Regulation of Animal Form and Tissue Pattern".
G.R. Martin, R. Timple, A. Rev. Cell Biol. 3, 57-85 (1987); "Laminin and Other Basement Membrane Components".
M. Takeichi, Development 102. (1988), pp. 639-655; "The cadherins: cell-cell adhesion molecules controlling animal morphogenesis".
P. Ekblom, D. Vestweber, R. Kemler, A. Rev.Cell Biol. 2, 27-47 (1986); "Cell-Matrix Interactions and Cell Adhesion During Development".
J.B. De Almeida, J.L. Stow, Am. J. Physiol. 260, C691-C700 (1991); "Disruption of microtubules alters polarity of basement membrane proteoglycan secretion in epithelial cells".
M.J. Rindler, I.E. Ivanov, D.D. Sabatini, J Cell Biol, 104, 231-241 (1987); "Microtubule-acting Drugs Lead to the Nonpolarized Delivery of the Influenza Hemagglutinin to the Cell Surface of Polarized Madin-Darby Canine Kidney Cells".
R.B. Kelley, Cell 61, 5-7 (1990); "Microtubules, Membrane Traffic, and Cell Organization".
B.R. Stevenson, J.D. M. Siliciano M.S., D.A. Goodenough, J.Cell Biol. 103, 755-766 (1986); "Identification of ZO-1: A High Molecular Weight Polypeptide Associated with the Tight Junction (Zonula Occludens) in a Variety of Epithelia".
I. Meza, G. Ibarra, M. Sabanero, A. Martinez-Palomo, M. Cereijido, J Cell Bio 87, 746-754 (1980); "Occluding Junctions and Cytoskeletal Components in a Cultured Transporting Epithelium".
B. Gumbiner, B. Stevenson, A. Grimaldi, J Cell Biol 107, 1575-87 (1988); "The Role of the Cell Adhesion Molecule Uvomorulin in the Formation and Maintenance of the Epithelial Junctional Complex".
S. Horikoshi, S. Kubota, M. G. R., Y. Yamada, K. P.E., Kidney Int. 39, 57-62 (1991); "E
Leary Louise N.
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