Inhibition of complement pathway by sea cucumber fractions

Details Inhibition of complement pathway by sea cucumber fractions Inhibition of complement pathway by sea cucumber fractions

1997-10-03

1999-11-23

Wityshyn, Michael G.

Drug, bio-affecting and body treating compositions

Extract, body fluid, or cellular material of undetermined...

424572, 424574, 514 2, 514 8, 514 21, 514 24, 514 25, 514 53, 514 54, 514822, 514885, A61K 3536, A61K 3800, A61K 3170, A61K 31715

Patent

active

059895926

ABSTRACT:
The present invention relates to methods for inhibiting the complement pathway in a mammal comprising administering an effective dose of a composition comprising an active ingredient selected from the group consisting of isolated sea cucumber (Phylum Echinodermata, Class Holothuroidea) body wall, isolated sea cucumber epithelial layer, isolated sea cucumber flower, sea cucumber fucosylated chondroitin sulfate, combinations thereof, active derivatives thereof or combinations of active derivatives thereof.

REFERENCES:
Takada, Y. et al., Inhibition of the classical and alternative pathways by amino acids and their derivatives. Immunology, vol. 34, pp. 509-515 (1978).
Becker, E.L., The relationship of the structure of phosphonate esters to their ability to inhibit chymotrypsin, trypsin, acetylcholinesterase and C'ra. Biochem. Biophys. Acta, vol. 147, pp. 289-296 (1967).
Conrow, R.B. et al., Synthetic modulators of the complement system. 1. Synthesis and biological activity of 5,5',5"-[1,3,6-Naphthalenetriyltris(sulfonylimino)]-tris[1,3-benzenedisulf onic acid] hexasodium salt. J. Med. Chem., vol. 23, pp. 240-242 (1980).
Hansch, C. et al., Structure-activity relationships in immunochemistry. 2. Inhibition of complement by benzamidines. J. Med. Chem., vol. 17, pp. 1160-1167 (1974).
De Clercq, E. et al., Anti-complement activity of polynucleotides. Biochem. Biophys. Res. Commun., vol. 67, pp. 255-263 (1975).

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